Diagnostic value of serum SAA and CA19-9 combined with endoscopic ultrasonography in preoperative staging of colorectal cancer
Objective To observe the value of serum amyloid A(SAA)and glycoprotein antigen(CA)19-9 combined with endoscopic ultrasonography(EUC)in diagnosing preoperative stages of colorectal cancer(CRC).Methods A total of 116 patients with pathologically confirmed CRC who were admitted to Nanjing Mingji Hospital from July 2020 to December 2022 were selected as the study subjects.All of them received EUC and detection of serum SAA and CA19-9 levels.ROC curve was used to analyze the value of serum SAA and CA19-9 levels combined with EUC in preoperative staging of CRC.The correlation between serum SAA level and CA19-9 level was analyzed.Results For the 116 patients with CRC,the results of pathological staging showed 22 cases in T1 stage,28 cases in T2 stage,46 cases in T3 stage and 20 cases in T4 stage,66 cases in N0 stage,30 cases in N1 stage and 20 cases in N2 stage,100 cases in M0 stage and 16 cases in M1 stage.The diagnostic results of EUC showed 18 cases in T1 stage,24 cases in T2 stage,40 cases in T3 stage and 15 cases in T4 stage,50 cases in N0 stage,22 cases in N1 stage and 14 cases in N2 stage,71 cases in M0 stage and 10 cases in M1 stage.The coincidence rates of EUC for diagnosing TNM stages of CRC were 83.62%,74.14%,and 69.83%,respectively.Serum SAA and CA19-9 levels in T4,T3 and T2 stages were higher than those in T1 stage.Serum SAA and CA19-9 levels in T4 and T3 stages were higher than those in T1 and T2 stages.Serum SAA and CA19-9 levels in T4 stage were higher than those in T1,T2 and T3 stages(P<0.05).Serum SAA and CA19-9 levels in N2 and N1 stages were higher than those in N0 stage.Serum SAA and CA19-9 levels in N2 stage were higher than those in N0 and N1 stages(P<0.05).Serum SAA and CA19-9 levels in M1 stage were higher than those in M0 stage(P<0.05).ROC curve analysis showed that the sensitivity and AUC of serum SAA and CA19-9 levels combined with EUC in diagnosing preoperative stages of CRC were higher than those of diagnosis alone(P<0.05).Pearson correlation analysis showed that serum SAA level was positively correlated with CA19-9 level(P<0.05).Conclusion EUC combined with serum SAA and CA19-9 levels is of high value in diagnosing preoperative stages of CRC.It can provide reference for treatment.
NETL
NSTL
万方数据
