Effects of Qingyi decoction combined with ulinastatin on the recovery of intestinal function and levels of inflammatory factors in patients with acute pancreatitis
Objective To evaluate the effects of Qingyi decoction combined with ulinastatin on the recovery of intestinal function and the levels of inflammatory factors in patients with acute pancreatitis.Methods From May 2020 to May 2023,111 patients with acute pancreatitis who visited Taihe County People's Hospital were selected,and 90 patients with acute pancreatitis were finally included as the study objects.Using a random alphabetical list,patients were divided into a control group(n=45)and an observation group(n=45).Both groups underwent conventional treatment,the control group received ulinastatin,while the observation group was treated with Qingyi decoction in addition to ulinastatin.Traditional Chinese Medicine symptom scores,clinical efficacy,recovery of intestinal function(time to return of bowel sounds,time to first flatus,time to first stool),levels of inflammatory factors(TNF-α,IL-1β,IL-6,PAF,MCP-1),and adverse reactions were compared between the two groups.Results After treatment,the total effective rate in the observation group was 95.56%,significantly higher than the 77.78%in the control group(P<0.05).Symptom scores for chest tightness,abdominal pain,body heat,thirst,nausea,vomiting,heaviness of the head and body,and unsatisfactory defecation,which are evaluated based on Traditional Chinese Medicine criteria,decreased in both groups after treatment.Moreover,scores in the observation group were notably lower than those in the control group(P<0.05).The recovery of intestinal function in the observation group was significantly superior to the control group(P<0.05).Both groups demonstrated a marked decrease in inflammatory factors post-treatment,and the levels in the observation group were significantly lower than those in the control group(P<0.01).The incidence of adverse reactions in the observation group was significantly lower than that in control group(P<0.05).Conclusion The clinical effect of Qingyi decoction and ulinastatin is more significant than that of ulinastatin alone in the treatment of acute pancreatitis.It can further shorten the time for intestinal function recovery,alleviate inflammation,and reduce the incidence of adverse reactions.