Objective To investigate the clinical value of Overlap anastomosis in laparoscopic right hemicolectomy.Methods From May 2022 to May 2023,70 patients who underwent laparoscopic right hemicolectomy in the Department of Gastrointestinal Surgery at Affiliated Hospital of Xuzhou Medical University were selected,32 underwent laparoscopic Overlap anastomosis(Overlap group)and 38 underwent routine extracorporeal anastomosis(control group).The surgical performance,postoperative recovery,inflammatory indicators and perioperative complications of the two groups were compared.Results The surgical incision length in the Overlap group was shorter than that in the control group[(5.1±0.8)cm and(6.9±1.5)cm,P<0.05],and the time of first exhaust and defecation postoperatively was earlier than that in the control group[(1.7±0.5)d and(2.3±0.6)d,P<0.05;(2.6±0.6)d and(2.9±0.6)d,P<0.05].There were no statistically significant differences in surgical time,intraoperative bleeding volume and lymph node dissection count between the two groups(all P>0.05).The leukocyte count,neutrophil count,and high-sensitivity C-reactive protein levels in the Overlap group in the follow-up 1 and 4 days after surgery were lower than those in the control group.The incidence of postoperative complications was 3.1%in the Overlap group and 7.9%in the control group,respectively,with no statistically significant difference(P>0.05).Conclusion Complete laparoscopic right hemicolectomy with Overlap anastomosis is safe,feasible,minimally invasive,and beneficial for rapid postoperative recovery of intestinal function.