Changes of peripheral blood ISGs and their relationship with curative effect of interferon therapy in patients with HBV infection
Objective To explore the changes of peripheral blood interferon-stimulated genes(ISGs)and their relationship with curative effect of interferon therapy in patients with hepatitis B virus(HBV)infection.Methods A total of 80 patients with HBV infection and 80 healthy controls in Daxing Teaching Hospital of Capital Medical University were enrolled as HBV group and control group between April 2018 and May 2023,respectively.The mRNA levels of myxovirus resistance protein A(MxA),ubiquitin-specific protease 18(USP18)and suppressors of cytokine signaling 3(SOCS3)in peripheral blood were compared between the two groups.The patients in the HBV group were treated with recombinant human interferon α-2b for 24 weeks.According to interferon response,they were divided into response group(n=38)and non-response group(n=42).The relationship between peripheral blood indexes and interferon response was analyzed by Logistic regression analysis,and changes of MxA mRNA,USP18 mRNA and SOCS3 mRNA before and after interferon treatment in the HBV group were observed.Results Before treatment,level of peripheral blood MxA mRNA in the HBV group was lower than that in the control group,while levels of USP18 mRNA and SOCS3 mRNA were higher than those in the control group(P＜0.05).Before treatment,level of peripheral blood MxA mRNA in the response group was higher than that in the non-response group,while levels of USP18 mRNA and SOCS3 mRNA were lower than those in the non-response group(P＜0.05).Logistic regression analysis showed that high expressions of USP18 mRNA and SOCS3 mRNA were risk factors of interferon non-response,while high expression of MxA mRNA was a protective factor of interferon response.Before treatment,after 2 weeks,12 weeks and 24 weeks of treatment,level of peripheral blood MxA mRNA in the interferon response group was higher than that in the non-response group,while levels of USP18 mRNA and SOCS3 mRNA were lower than those in the non-response group(P＜0.05).Conclusion In the treatment of HBV infection with interferon,interferon response effect is better in those with high expression of MxA and low expressions of USP18 and SOCS3.
Hepatitis B virusInterferonInterferon-stimulated genesTreatment response
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