Clinical study of ribavirin combined with compound lactobacillus acidophilus in the treatment of children with rotavirus enteritis
Objective To explore the therapeutic effect of ribavirin combined with compound lactobacillus acidophilus on children with rotavirus enteritis(RVE)and its effects on serum advanced glycation end products(AGEs),inflammatory factors,and intestinal microbiota.Methods A total of 100 children with RVE in Jieshou City People's Hospital from March 2019 to November 2023 were selected.They were divided into a control group(compound lactobacillus acidophilus,n=50)and an observation group(ribavirin+compound lactobacillus acidophilus,n=50)using a random number table method.The clinical efficacy,serum AGEs and inflammatory factor levels,gut microbiota levels,intestinal mucosal barrier indicators and gastrointestinal hormones,as well as the conversion of rotavirus to negative and medication safety between the two groups were compared.Results The clinical efficacy of the observation group was higher than that of the control group(94.54％vs.81.81％,P＜0.05).The levels of AGEs and inflammatory factors in the observation group were lower than those in the control group(both P＜0.05).The numbers of Escherichia coli and Enterococcus in the observation group was lower than those in the control group,while the numbers of Lactobacillus and Bifidobacterium were higher than those in the control group(both P＜0.05).The intestinal mucosal barrier indicators and gastrointestinal hormone levels in the observation group were lower than those in the control group(both P＜0.05).The negative conversion rate of rotavirus in the observation group was higher than that in the control group(92.00％vs.78.00％,P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(8.00％vs.12.00％,P＞0.05).Conclusion The combination of ribavirin and compound lactobacillus acidophilus can significantly alleviate symptoms,regulate the levels of intestinal flora,serum AGEs and inflammatory factor levels,with good safety.
Rotavirus enteritisRibavirinCompound lactobacillus acidophilusAdvanced glycation end productsInflammatory factorsIntestinal microbiota
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