首页|重视炎症性肠病和代谢相关脂肪性肝病间的串话机制研究

重视炎症性肠病和代谢相关脂肪性肝病间的串话机制研究

扫码查看
原文链接
  • 万方数据
  • 维普
炎症性肠病(IBD)患者代谢相关脂肪性肝病(MASLD)患病率显著升高,二者是共病或IBD肠外表现目前尚无定论.很大程度上,IBD和MASLD有共同的分子调控机制和潜在治疗靶点,然而二者之间的因果关系和潜在相互作用尚未阐明.本文阐述了 IBD相关MASLD患病率、临床病程、发病机制上的现有认知,尤其呼吁重视二者串话机制研究.
Strengthen the investigation of the cross-talk mechanism between inflammatory bowel disease and metabolic dysfunction-associated steatotic liver disease
The prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)in patients with inflammatory bowel disease(IBD)is significantly increased,but it remains unclear whether the two diseases are co-existence or extraintestinal manifestations of IBD.Largely,IBD and MASLD share common molecular regulatory mechanisms and potential therapeutic targets,but the causal relationship and potential interplay of MASLD and IBD is not well elucidated.This article reviews the current understanding of the prevalence,clinical course and pathogenesis of MASLD in IBD,especially calls attention to both the cross-talk mechanism study.

Inflammatory bowel diseaseUlcerative colitisCrohn's diseaseMetabolic dysfunction-associated steatotic liver diseaseCross-talk mechanism

陈利、杨长青、朱风尚

展开 >

200065 上海,同济大学附属同济医院消化科

炎症性肠病 溃疡性结肠炎 克罗恩病 代谢相关脂肪性肝病 串话机制

上海市临床重点专科建设项目省部共建中亚高发病成因与防治国家重点实验室项目新疆科技厅科技援疆项目

shslczdzk06801SKL-HIDCA-2021-DX92021E02075

2024

10.3877/cma.j.issn.2095-2015.2024.05.001

中华消化病与影像杂志(电子版)
中华医学会

中华消化病与影像杂志(电子版)

CSTPCD
影响因子：0.641
ISSN：2095-2015
年,卷(期)：2024.14(5)