Objective To explore the fibrinogen to albumin ratio(FAR),C-reactive protein(CRP),neutrophil to albumin ratio(NAR)of ulcerative colitis(UC)patients and their relationship with the condition and prognosis.Methods A retrospective analysis was conducted on the clinical data of 102 patients with UC treated in Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from November 1,2020 to December 31,2022.The study group was divided into relief group,mild group,moderate group,and severe group according to the modified Mayo endoscopic score,and 100 healthy individuals during the same period were selected as the control group.Patients with UC were followed up to observe the occurrence of cancer,and were divided into cancer group and non-cancer group based on the presence or absence of cancer.The levels of relevant clinical indicators in each group were compared,and logistic regression and receiver operating curve(ROC)were used to analyze the relationship between FAR,CRP and NAR and the activity and prognosis of UC patients.Results The study group had lower BMI than the control group,but significantly higher white blood cell count,platelet count,erythrocyte sedimentation rate(ESR),FAR,CRP,and NAR than the control group,with statistically significant differences(P＜0.05).The differences in BMI,white blood cell count,platelet count,ESR,FAR,CRP,and NAR among different disease subgroups were statistically significant(P＜0.05).Multivariate logistic regression analysis showed that white blood cell count,platelet count,ESR,FAR,CRP,and NAR were independent factors affecting the severity of UC(P＜0.05).White blood cells,platelets,ESR,FAR,CRP,and NAR were used to evaluate the condition of UC patients,and the ROC results showed that the area under the curve was 0.730,0.694,0.830,0.826,0.874,and 0.832,respectively.After follow-up,it was found that a total of 5 cases(2.37％)of UC patients developed cancer.There was a correlation between white blood cell count,ESR,NAR,and whether UC patients had cancer(P＜0.05).The ROC analysis results of white blood cells,ESR,and NAR predicting cancer progression in UC patients indicated that the area under the curve was 0.808,0.811 and 0.825,respectively,with statistically significant differences(P＜0.05).Conclusion FAR,CRP,and NAR have good value in evaluating the condition of UC patients,and NAR has good value in predicting whether UC patients will undergo cancer.
Ulcerative colitisFibrinogen to albumin ratioNeutrophil to albumin ratioC-reactive proteinDisease assessmentPrognosis
维普
万方数据
