Relationship between Helicobacter pylori infection and inflammatory cytokines and pathological features in patients with chronic atrophic gastritis
Objective To explore the relationship between Helicobacter pylori(Hp)infection and inflammatory cytokines and pathological characteristics in patients with chronic atrophic gastritis(CAG).Methods A total of 152 patients with CAG admitted to Daqing Fourth Hospital from January 2020 to January 2021 were selected for gastroscopy examination,and tissue samples of gastric mucosal lesions were collected.The infection status of Hp was analyzed,and the correlation between Hp infection and inflammatory cytokines and pathological characteristics was analyzed.Results There were 84 positive cases of Hp infection and 68 negative cases in 152 patients with CAG.The negative and positive groups of Hp showed weak positive expression of IL-1,and the positive and strong positive expression rates of IL-1 in the positive group were significantly higher than those in the negative group(P＜0.05).TNF-α was mainly strongly positive in both groups of interstitial inflammatory cells,while TNF-β was mainly positive,with no statistically significant difference(P＞0.05).There was no statistically significant difference between the two groups of gastric pit epithelium(P＞0.05),with weak positive IL-1 and strong positive TNF-α.The negative group showed strong positivity for TNF-β,while the positive group showed positivity,but there was no statistically significant difference(P＞0.05).The negative group was mainly characterized by moderate inflammation,followed by mild inflammation,while the positive group was mainly characterized by moderate inflammation,followed by severe inflammation,with a statistically significant difference(P＜0.01).There was no statistically significant difference in the degree of atrophy and intestinal metaplasia between the negative and positive groups of Hp(P＞0.05).Correlation analysis showed that the degree of chronic inflammation was positively correlated with the IL-1 levels of gastric pit epithelium and stromal inflammatory cells in patients with CAG(P＜0.05),but not with the levels of TNF-αand TNF-β(P＞0.05).There was no correlation between atrophy,intestinal metaplasia and the levels of IL-1,TNF-α and TNF-β in the gastric pit epithelium and stromal inflammatory cells(P＞0.05).Conclusion The expression of IL-1 in gastric pit epithelium and stromal inflammatory cells is related to Hp infection and the degree of CAG,but its relationship with atrophy and intestinal metaplasia needs further research.
万方数据
维普
