Efficacy of Shixiao powder combined with Weifuchun in the treatment of chronic atrophic gastritis and its effect on serum immune receptors and inflammatory factors
Objective To investigate the efficacy of Shixiao powder and Weifuchun in the treatment of chronic atrophic gastritis and its effect on serum Toll-like receptor 4(TLR4),interleukin-4(IL-4)and tumor necrosis factor-α(TNF-α)levels.Methods A total of 92 patients with chronic atrophic gastritis admitted to Shenzhen Luohu District People's Hospital from September 2019 to April 2022 were selected and divided into an observation group(n=46)and a control group(n=46)based on different treatment methods.The control group received treatment with Weifuchun,while the observation group received treatment with Shixiaosan in addition to the control group.The treatment efficacy,serum TLR4,IL-4,and TNF-α level,Kimura Takemoto classification score,and incidence of adverse reactions were compared between the two groups.Results After 3 months of treatment,the effective rate of treatment in the observation group was significantly higher than that in the control group,and the traditional Chinese medicine syndrome score was lower than that in the control group(P＜0.05).The levels of the serum TLR4,IL-4,and TNF-α in the observation group[(12.76±2.38)μg/mL,(32.62±6.18)ng/L,and(1.16±0.34)pg/ml]were significantly lower than those in the control group[(23.16±5.36)]μg/mL,(38.34±6.15)ng/L,(1.38±0.22)pg/ml](P＜0.05).The Kimura Takemoto classification score in the observation group was significantly lower than that in the control group(P＜0.05),and the incidence of adverse reactions in the observation group was lower than that in the control group(P＜0.05).Conclusion The combination of Shixiao power and Weifuchun can effectively alleviate the body's oxidative stress response,alleviate symptoms,avoid adverse reactions,and improve treatment efficiency.
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