Effects of multi-slice spiral CT parameters,carcinoembryonic antigen,mismatch repair gene,and pathological indicators on prognosis of colorectal cancer
Objective To analyze the correlation between multi-slice spiral CT,carcinoembryonic antigen(CEA),mismatch repair gene(MMR)protein level,pathological indicators and prognosis in patients with colorectal cancer.Methods A total of 100 patients with colorectal cancer admitted to Huainan Oriental Hospital Group General Hospital from January 2019 to September 2021 were included.According to their 3-year survival,the patients were divided into survival group and death group.The differences in multi-slice spiral CT characteristics,CEA levels,and MMR protein detection results of the pathological tissues removed during operation between the two groups were sorted out and compared.Logistic multivariate regression analysis was used to summarize the related factors affecting the prognosis of patients with colorectal cancer.Results All 100 patients were effectively followed up,with a median follow-up time of 69 months.At the end of 3-year follow-up,31 patients died and 69 patients survived,with a 3-year mortality rate of 31.00%.Logistic multivariate regression analysis showed that the plain scan CT value≤40 HU,enhanced scan CT value≤75 HU,increased peripheral fat density,thickened blood vessels,uneven tumor enhancement,lymph node metastasis,CEA≥13.50 μg/L,tumor diameter≥5 cm,TNM stage Ⅲ,and moderate to poor differentiation were independent risk factors affecting the 3-year survival rate of colorectal cancer,and the loss of MMR protein expression was a protective factor(P<0.05).Conclusion The prognosis of colorectal cancer patients is closely related to the characteristics of multi-slice spiral CT,CEA and pathological indexes,and the loss of MMR protein may be associated with a higher 3-year survival rate.
万方数据
维普
