Study on the therapeutic effect of vitamin D combined with povidone bromide tablets on diarrhea type patients with irritable bowel syndrome and its impact on intestinal barrier function indicators
Objective To explore the therapeutic effect of vitamin D combined with povidone bromide tablets in the treatment of diarrhea predominant irritable bowel syndrome(IBS-D)and its impact on intestinal barrier function indicators.Methods A total of 108 patients with IBS-D who received treatment at Qinhuangdao First Hospital from January 2022 to January 2024 were selected and randomly divided into two groups based on the order of admission.Among them,54 patients in the control group received treatment with povidone bromide tablets,while 54 patients in the observation group received treatment with vitamin D combined with povidone bromide tablets,both of which were treated for 4 weeks.The clinical efficacy,gut microbiota,gut barrier function indicators,25 hydroxyvitamin D[25-(OH)]levels,and IBS Clinical Symptom Severity Scale(IBS-SSS)scores were compared between the two groups.Results The total clinical effective rate of the observation group was 94.44%,which was higher than that of the control group(79.63%,χ2=5.441,P<0.05).After 2 and 4 weeks of treatment,the numbers of Lactobacilli and Bifidobacteria in the observation group were higher than those in the control group,and the number of Enterobacilli was lower than that in the control group(t=2.164,2.843,3.016,2.850,3.117,2963,P<0.05).The serum 25 hydroxyvitamin D[25-(OH)]in the observation group was higher than that in the control group,and the serum diamine oxidase(DAO),D-lactate,and intestinal fatty acid binding protein(IFBP)were lower than those in the control group(t=3.152,4.274,3.975,4.628,3.728,3.415,4.416,3.521,P<0.05).The IBS-SSS scores in all dimensions in the observation group were lower than those in the control group(t=5.729,5.823,4.962,4.683,5.382,5143,4.670,4.527,5.106,5.317,P<0.05).Conclusion The combination of vitamin D and povidone bromide tablets can effectively alleviate the clinical symptoms of IBS-D,regulate intestinal microbiota,repair intestinal barrier function,and thus improve the therapeutic effect.
万方数据
维普
