首页|静息心率对10年心血管疾病风险的影响

静息心率对10年心血管疾病风险的影响

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目的:探究静息心率与10年心血管疾病风险之间的关系,为心血管疾病的防治提供科学依据。方法:本研究为横断面研究,研究对象来自中国动脉粥样硬化性心血管疾病风险预测研究(China­PAR)的基线调查,涉及全国15个省市18岁及以上人群117 309人。以静息心率60、70、80、90次/min作为切点,将其分为5组(<60次/min组、60~69次/min组、70~79次/min组、80~89次/min组和≥90次/min组),利用China­PAR模型计算研究对象10年心血管疾病风险,并以≥10%作为高风险人群,利用多因素Logistic回归模型,以10年心血管疾病高风险为终点,计算不同静息心率对其的比值比(OR)及其95%可信区间(CI)。结果:性别、年龄调整后,10年心血管疾病风险水平随着静息心率的增加而增加,从静息心率<60次/min的2.31%上升至静息心率≥90次/min的2.67%,高风险人群的占比也从5.15%上升至7.09%。调整性别、年龄、文化程度、婚姻状况、职业、工作相关体力活动和家庭人均月收入后,静息心率每增加10次/min,出现10年心血管疾病高风险的概率升高9%(OR=1.09,95% CI 1.06~1.11)。以静息心率70~79次/min作为参照,静息心率80~89和≥90次/min人群中,出现高风险的概率分别升高至1.21(95% CI 1.14~1.29)倍和1.24(95% CI 1.14~1.35)倍。静息心率与10年心血管疾病的相关性在女性、城市人群、家庭人均月收入较高人群中更加明显,而在农民、中度及以上工作相关体力活动人群中相对较弱。结论:静息心率与10年心血管疾病风险独立相关,可作为心血管疾病高危人群初筛和干预效果评价的简便易行的辅助指标,尤其是在女性、城市人群、较高收入人群和体力活动不足的人群中。
Association between resting heart rate and ten-year risk of cardiovascular disease in China
Objective:To evaluate the association between resting heart rate and ten-year risk of cardiovascular disease, and provide evidence for the prevention and treatment of cardiovascular disease.Methods:This cross-sectional study was from the baseline survey of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR), including 117 309 participants aged 18 years and above in 15 provinces in China. Participants were categorized into five groups (<60, 60-69, 70-79, 80-89, ≥90 beats/min) based on resting heart rates. The ten-year cardiovascular disease risks were estimated using the China-PAR equations, and those with ten-year risk ≥10% were identified as high-risk individuals. Odds ratios (OR) and 95% confidence intervals (CI) of high-risk for cardiovascular disease associated with resting heart rates were estimated using multivariate Logistic regression.Results:Sex- and age-adjusted levels of ten-year cardiovascular disease risk increased with elevated resting heart rate, which increased from 2.31% among participants at resting heart rates <60 beats/min to 2.67% among those at ≥90 beats/min. Similar trend was observed for prevalence of high-risk, which climbed from 5.15% among individuals at <60 beats/min to 7.09% among those at ≥90 beats/min. After adjustment for sex, age, education, marital status, occupation, work-related physical activity, and household income per capita, an increment of 10 beats/min in resting heart rate was associated with a 9% increment in prevalence of high-risk for cardiovascular disease (OR=1.09, 95% CI 1.06-1.11). Compared with participants at resting heart rate 70-79 beats/min, those at 80-89 and ≥90 beats/min had ORs of 1.21 (95% CI 1.14-1.29) and 1.24 (95% CI 1.14-1.35), respectively. The association between resting heart rate and ten-year risk of cardiovascular disease was stronger in women, participants lived in urban and with higher monthly household income per capita, but weaker in farmers and population with moderate-heavy work-related physical activity.Conclusion:Resting heart rate was independently associated with ten-year risk of cardiovascular disease. It could be used as a simple and auxiliary clinical indicator in pre-screening for high-risk population and evaluation for the effectiveness of cardiovascular disease interventions, particularly in women, population lived in urban, with higher income or with physical inactivity.

沈安娜、李建新、刘芳超、黄克勇、付真彦、鲁向锋、顾东风

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100037 北京,北京协和医学院 国家心血管病中心 中国医学科学院阜外医院流行病研究部 中国医学科学院心血管流行病学重点实验室

830000 乌鲁木齐,新疆医科大学第一附属医院心脏中心

心血管疾病 静息心率 10年心血管疾病风险 高风险 横断面研究

中国医学科学院医学与健康科技创新工程中国医学科学院医学与健康科技创新工程中国医学科学院医学与健康科技创新工程国家重点研发计划国家重点研发计划国家重点研发计划新疆科技支疆项目

2021-I2M-1-0102019-I2M-2-0032017-I2M-1-0042017YFC02117002018YFE01153002021YFC25006052020E0278

2023

中华心脏与心律电子杂志

中华心脏与心律电子杂志

ISSN:
年,卷(期):2023.11(1)
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