Effect of assisted reproductive technology on retinopathy of prematurity
Objective To observe the effect of assisted reproductive technology(ART)on retinopathy of prematurity(ROP)in preterm infants.Methods A retrospective clinical study.From January 2016 to January 2020,639 preterm infants who were hospitalized at Children's Hospital of Zhengzhou University and underwent fundus screening at a gestational age ≤32 weeks were included in the study.There were 366 males and 273 females.Gestational age at birth were(28.3±1.4)weeks;birth weight were(1 153.8±228.8)g.Severe ROP was detected in 60 cases(9.4％,60/639);120 were ART recipients,and 519 were naturally conceived,and were divided into the ART group and the control group accordingly.The incidence of gestational diabetes mellitus(x2=21.675),pulmonary surfactant application(x2=13.558),and twin births(yes)(x2=145.568)in mothers of the children examined in both groups were significantly higher than that of the control group,and the difference were statistically significant in all cases(P＜0.001).Comparison of quantitative data between groups was performed by t-test,and comparison of count data was performed by x2 test;logistic regression was used to analyze the effect of ART on the incidence of ROP.Results Of the 60 cases of severe ROP,18(15.0％,18/120)and 42(8.1％,42/519)cases were in the ART group and control group,respectively.The incidence of severe ROP was significantly higher in the ART group than in the control group,and the difference was statistically significant(x2=4.680,P=0.024).Compared with the control group,the incidence of severe ROP was significantly higher in the ART group for gestational age at birth＜28 weeks and birth weight＜1 000 g,and the differences were statistically significant(x2=10.116,3.785;P=0.002,0.037).Logistic regression analysis showed that ART was a non-independent risk factor for the occurrence of ROP(P＞0.05).Conclusion Assisted reproductive technology may have a certain influence on the occurrence of ROP,which is not an independent factor.
Assisted reproductive technologyRetinopathy of prematurityGestational ageBirth weight
NETL
NSTL
万方数据
维普
