辅助生殖技术对早产儿视网膜病变的影响
Effect of assisted reproductive technology on retinopathy of prematurity
孙志宏 1孙慧清1
作者信息
- 1. 郑州大学附属儿童医院河南省儿童医院郑州儿童医院早产儿病房,郑州 450028
- 折叠
摘要
目的 观察辅助生殖技术(ART)对早产儿视网膜病变(ROP)的影响.方法 回顾性临床研究.2016年1月至2020年1月于郑州大学附属儿童医院住院并接受眼底筛查胎龄≤32周的早产儿639名纳入研究.其中,男性366名,女性273名;出生胎龄(28.3±1.4)周;出生体重(1 153.8±228.8)g.检出重度ROP者60例(9.4％,60/639).ART者120名,自然受孕者519名,据此分为ART组、对照组.两组受检儿母亲孕期糖尿病(x2=21.675)、肺表面活性物质应用(x2=13.558)、双胎(是)(x2=145.568)发生率显著高于对照组,差异均有统计学意义(P＜0.001).组间定量资料比较行t检验,计数资料比较行x2检验;logistic回归分析ART对ROP发生率的影响.结果 60例重度ROP患儿中,ART组、对照组分别为18(15.0％,18/120)、42(8.1％,42/519)例;ART组重度ROP发生率显著高于对照组,差异有统计学意义(x2=4.680,P=0.024).与对照组比较,ART组出生胎龄＜28周者和出生体重＜1 000g者重度ROP发生率显著增高,差异均有统计学意义(x2=10.l16、3.785,P=0.002、0.037).Logistic回归分析结果显示,ART是影响ROP发生的非独立危险因素(P＞0.05).结论 ART对ROP的发生可能产生一定影响,为非独立影响因素.
Abstract
Objective To observe the effect of assisted reproductive technology(ART)on retinopathy of prematurity(ROP)in preterm infants.Methods A retrospective clinical study.From January 2016 to January 2020,639 preterm infants who were hospitalized at Children's Hospital of Zhengzhou University and underwent fundus screening at a gestational age ≤32 weeks were included in the study.There were 366 males and 273 females.Gestational age at birth were(28.3±1.4)weeks;birth weight were(1 153.8±228.8)g.Severe ROP was detected in 60 cases(9.4％,60/639);120 were ART recipients,and 519 were naturally conceived,and were divided into the ART group and the control group accordingly.The incidence of gestational diabetes mellitus(x2=21.675),pulmonary surfactant application(x2=13.558),and twin births(yes)(x2=145.568)in mothers of the children examined in both groups were significantly higher than that of the control group,and the difference were statistically significant in all cases(P＜0.001).Comparison of quantitative data between groups was performed by t-test,and comparison of count data was performed by x2 test;logistic regression was used to analyze the effect of ART on the incidence of ROP.Results Of the 60 cases of severe ROP,18(15.0％,18/120)and 42(8.1％,42/519)cases were in the ART group and control group,respectively.The incidence of severe ROP was significantly higher in the ART group than in the control group,and the difference was statistically significant(x2=4.680,P=0.024).Compared with the control group,the incidence of severe ROP was significantly higher in the ART group for gestational age at birth＜28 weeks and birth weight＜1 000 g,and the differences were statistically significant(x2=10.116,3.785;P=0.002,0.037).Logistic regression analysis showed that ART was a non-independent risk factor for the occurrence of ROP(P＞0.05).Conclusion Assisted reproductive technology may have a certain influence on the occurrence of ROP,which is not an independent factor.
关键词
辅助生殖技术/早产儿视网膜病变/出生胎龄/出生体重Key words
Assisted reproductive technology/Retinopathy of prematurity/Gestational age/Birth weight引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据