Elevated blood pressure increases risk of proliferative diabetic retinopathy:a Mendelian randomization study
Objective Mendelian randomization(MR)was used to analyze the potential relationship between blood pressure and proliferative diabetic retinopathy(PDR).Methods Two-sample MR analysis was performed using summary statistics from genome-wide association studies.Systolic blood pressure(SBP)and diastolic blood pressure(DBP)were selected as the exposure,PDR as the outcome.The instrumental variable of SBP and DBP came from the publicly available data of the the UK Medical Research Council Comprehensive Epidemiology Unit and Neale Laboratory;the outcome data(8 681 cases in the case group,204 208 cases in the control group,European population)are from the FinnGen database.Inverse variance weighting(IVW)and weighted median(WM)were used to analyze the potential relationships between SBP,DBP and PDR.Results MR analysis showed that IVW[SBP:odds ratio(OR)=1.36,95％confidence interval(CI)1.17-1.57,P=4.22E-05;DBP:OR=1.29,95％CI 1.11-1.51,P=8.6E-04],WM(SBP:OR=1.33,95％CI 1.07-1.66,P=0.009;DBP:OR=1.28,95％CI=1.03-1.59,P=0.002).The results showed that elevated SBP and DBP increased the risk of PDR.Conclusion Blood pressure(SBP,DBP)change is positively correlated with the risk of PDR.
万方数据
维普
