Research progress on cellular senescence and senescence-associated secretory phenotype in pathogenesis and treatment of age-related macular degeneration
Age-related macular degeneration(AMD)is one of the leading irreversible causes of blindness in China.The pathogenesis of AMD is not fully understood at present.Under various stress conditions,cellular senescence is activated,characterized by telomere shortening,mitochondrial dysfunction,DNA damage,and the release of various senescence-related secretory phenotype factors.Senescence is implicated in the pathogenesis of AMD through multiple pathways,contributing to chronic inflammation and the onset and progression of AMD.Mechanisms such as oxidative stress,lipofuscin,β amyloid protein and the membrane attack complex have become hotspots of study in the pathogenesis of AMD.The cyclic guanosine phosphate-adenosine synthase-interferon stimulating factor synthase-stimulator of interferon gene pathway has emerged as a critical signaling pathway in the early development of AMD,providing direction for further research on AMD.Currently,senolytics,selective agents targeting the induction of senescent cell apoptosis,show significant potential in the treatment of AMD.The integration of new technologies with cellular senescence may offer a novel approach to AMD treatment,and intervening in the AMD treatment through anti-cellular senescence pathways holds promising prospects.
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