Objective To observe alterations in center retinal thickness(CRT)in patients diagnosed with central retinal artery occlusion(CRAO)before and after undergoing superselective arterial thrombolysis(IAT)treatment.Methods A retrospective clinical study.From August 2022 to September 2023,12 patients(12 eyes)diagnosed with CRAO and treated with IAT at the ophthalmology department of Shenzhen Second People's Hospital.Among these patients,there were 8 males(8 eyes)and 4 females(4 eyes),all experiencing unilateral onset.The mean age was(47.00±15.06)years.The mean duration from onset to thrombolysis was(30.00±30.42)h.All eyes underwent best corrected visual acuity(BCVA)and optical coherence tomography(OCT)assessments;additionally,6 eyes underwent Fluorescein fundus angiography(FFA).BCVA assessments were conducted using a standard logarithmic chart and transformed into logarithm of the minimum angle of resolution(logMAR)values for statistical analysis.The OCT measured CRT at various locations around the macular fovea(M),including upper(S1,S3),lower(I1,I3),nasal(N1,N3),and temporal(T1,T3)areas at 1 mm and 3 mm distances from the fovea.CRT was defined as the vertical distance between the inner retinal boundary membrane and the inner interface of the retinal pigment epithelial layer.Pre-and post-IAT examinations were performed using the same equipment and methodologies within a 24-hour interval.Changes in CRT at different macular points were compared and observed,while arterial imaging time changes were assessed in 6 eyes that underwent FFA.Paired t-tests were utilized to analyze logMAR BCVA,CRT at different locations,and arterial imaging time pre-and post-treatment.Results Prior to IAT treatment,the logMAR BCVA for the affected eye was 3.48±1.42,while the arterial imaging time for the 6 eyes undergoing FFA examination was(27.50±5.47)s.After 24 hours,the logMAR BCVA had improved to 2.35±1.59 for the affected eye,with 9 eyes showing varying degrees of BCVA improvement.The arterial imaging time was(24.17±7.28)s post-treatment.The differences in logMAR BCVA and arterial imaging time before and after treatment were found to be statistically significant(t=2.489,3.262;P＜0.05).Additionally,the comparison of CRT at S3(t=2.871),I1(t=2.325),and T3(t=3.446)before and after treatment yielded statistically significant differences(P＜0.05).Conversely,the comparison of CRT at S1(t=1.879),I3(t=1.915),N1(t=2.001),N3(t=1.987),T1(t=2.180),and M(t=-0.490)showed no statistically significant differences(P＞0.05).Conclusions IAT treatment for CRAO has been shown to be effective in achieving therapeutic effects by reducing CRT in the macular area.However,the short-term improvement in retinal edema in the macular area is limited.
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