Changes of some peripheral blood cells in patients with non-arteritis central retinal artery occlusion
Objectives To explore the changes of some peripheral blood cells related to inflammation in patients with non-arteritis central retinal artery occlusion(NA-CRAO).Methods A retrospective clinical study.From July 2019 to July 2021,a total of 218 patients with NA-CRAO hospitalized(NA-CRAO group)in Department of Ophthalmology,Xi'an People's Hospital(Xi'an Fourth Hospital)and 218 patients with routine physical examination(control group)during the same period were included in the study.There were no significant differences in age(t=0.60),sex composition ratio(x3=0.83)and body mass index(t=0.77)between the two groups(P＞0.05).0.2 ml fasting peripheral blood was collected from the subject,and white blood cells(WBC),neutrophils(NEUT),lymphocytes(LYMPH),red blood cells(RBC),RBC distribution width(RDW),platelets(PLT),mean PLT volume(MPV),and large PLT ratio(PLCR)were detected.The NEUT/LYMPH ratio(NLR)and PLT/LYMPH ratio(PLR)were calculated.t test was used to compare measurement data between groups.Multiple logistic regression analysis was performed for blood cells with P＜0.05.The receiver operating characteristic curve(ROC curve)was used to calculate the area under the curve(AUC)and 95％confidence interval(95％CI)of each inflammatory indicator,and the optimal cutoff value was determined according to the Jorden index(sensitivity+specificity-1).Results Compared with control group,WBC,NEUT,NLR,RDW,PLR were increased in NA-CRAO group,while RBC and LYMPH were decreased,with statistical significance(t=9.68,12.43,9.47,3.64,5.54,5.18,0.46;P＜0.001).There was no significant difference in PLT,MPV and PLCR between the two groups(t=0.32,1.56,0.84;P＞0.05).Multivariate logistic regression analysis showed that NLR was a possible risk factor for the occurrence of NA-CRAO(odds ratio=2.51,95％CI 0.780-0.859,P=0.031).ROC curve analysis showed that the AUC predicted by NLR was 0.819,the optimal critical value was 3.05,and the sensitivity and specificity were 59.2％and 92.7％,respectively.Conclusions In peripheral blood cells of NA-CRAO patients,NEUT is significantly increased and LYMPH is decreased.NLR is a possible risk factor for NA-CRAO.
Non-arteritis central retinal artery occlusionPeripheral bloodBlood cellsInflammation
NETL
NSTL
万方数据
