中华眼底病杂志2024,Vol.40Issue(12) :964-968.DOI:10.3760/cma.j.cn511434-20240730-00287

羟氯喹相关视网膜毒性的研究进展

Research progress of hydroxychloroquine related retinal toxicity

李月明 段连海 吴虎强 康剑书
中华眼底病杂志2024,Vol.40Issue(12) :964-968.DOI:10.3760/cma.j.cn511434-20240730-00287

羟氯喹相关视网膜毒性的研究进展

Research progress of hydroxychloroquine related retinal toxicity

李月明 1段连海 2吴虎强 2康剑书3
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作者信息

  • 1. 云南大学附属医院眼科,昆明 650000;云南省中医医院眼科,昆明 650000
  • 2. 云南省中医医院眼科,昆明 650000
  • 3. 云南大学附属医院眼科,昆明 650000
  • 折叠

摘要

羟氯喹是广泛用于治疗自身免疫性疾病和皮肤疾病的药物,主要用于如系统性红斑狼疮、类风湿性关节炎等疾病的治疗.该药物对患者有诸多益处,然而长期使用该药物可能导致患者视网膜的慢性毒性改变,严重影响患者视力及生活质量,但目前国内外对此类研究报道较少,临床上容易发生漏诊和误诊.眼科医生应该熟悉羟氯喹相关视网膜毒性的病因病理和临床表现,通过相关辅助检查及早发现药物对患者视网膜的毒性反应,并及时建议患者停药,从而有效地降低患者因视网膜毒性而导致的视力丧失的风险,在患者得到羟氯喹很好的治疗效果的同时,减少其对视网膜的不良影响.

Abstract

Hydroxychloroquine is widely used in the treatment of autoimmune diseases and skin diseases,mainly for the treatment of diseases such as systemic lupus erythematosus,rheumatoid arthritis and other diseases.Hydroxychloroquine has many benefits to patients,but long-term use of the drug may lead to retinal chronic toxicity changes,seriously affect the patient's vision and quality of their lives.However,there are few studies on retinal toxicity of hydroxychloroquine in the world,easy to miss diagnosis and misdiagnosis clinically.ophthalmologists should increase the knowledge with the etiology and pathology of hydroxychloroquine retinal toxicity,through relevant auxiliary check early detection of the drug to the retina and timely suggest patients to stop.This can effectively reduce the risk of vision loss caused by retinal toxicity,and reduce the adverse effects of hydroxychloroquine on the retina while patients get a good treatment effect.

关键词

羟氯喹/视网膜毒性/视力损害/综述

Key words

Hydroxychloroquine/Retinal toxicity/Visual impairment/Review

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出版年

2024
中华眼底病杂志
中华医学会

中华眼底病杂志

CSTPCD北大核心
影响因子:0.928
ISSN:1005-1015
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