Objective By reviewing the new requirements of NIH Policy for Data Management and Sharing(DMS Poli-cy)issued by the National Institutes of Health in 2020 and summarizing the trends of scientific data management and sharing in the future,this study provided enlightenment and reference for China to improve the construction of scientific data management policy system and promote the practice of biomedical scientific data sharing.Methods Using a comparative historical approach,this study compared the two editions of DMS policy published in 2003 and 2020 from the aspects of policy structure and policy contents.Results The new DMS policy presented the following trends:mandatory data sharing,high-quality data submission,prospective data management,and intensified privacy protection.Conclusions According to the national conditions of China,this paper put forward the following suggestions:promoting mandatory data sharing led by research funders,improving the quality evaluation system for scientific data submission;forming a prepositioned data management and sharing mode;and devel-oping guidelines for secure sharing and use of data derived from human participants.