Abstract
Objective:To investigate the associated pathognesis of higher clinical coexistence of obstructive sleep apnea hypopnea syndrome(OSAHS) and metabolic syndrome (MS) in elderly snorers.Methods:Through polysomnography examination, 69 elderly habitual snorers weredivided into simple snorers (control group) and OSAHS patients who were further divided into mild-to-moderate and severe OSAHS groups basedon their apnea hypopnea index (AHI) and the lowest pulse oxygen saturation (LSpO2) during sleep respectively. The incidences of MS werecompared among different groups. Correlation was analyzed among polysomnography parameters-AHI, LSpO2 and average pulse oxygensaturation (ASpO2),MS-associated parameters-fasting blood glucose (FBG),total cholesterol (TCH),triglyceride(TG),high-densitylipoprotein cholesterol (HDL),low-density lipoprotein cholesterol (LDL),insulin and proinsulin (PI),HOMA index and blood pressure(Bp),as well as some body indexes-body mass index (BMI),waist circumference (WC) and neck circumference (NC).Results:CoexistingMS was found in 28% of all the OSAHS patients. The incidences of MS in severe OSAHS groups were significantly higher than incontrol group(P＜0.05).Spearman correlation analysis indicated that HOMA index and PI were negatively correlated with nocturnalLSpO2 and ASpO2 significantly. There were no statistically significant correlation of HOMA index and PI with AHI. LSpO2 and ASpO2were negatively correlated with BMI, WC, NC and diastolic Bp but positively correlated with TCH and HDL significantly. UnivariateLogistic regression analysis suggested that the HOMA index and PI were risk factors of severe OSAHS and the odds ratio (OR) was1.907(1.312～2.796)(P＜0.01)and 1.703(1.162～2.497)(P＜0.01)respectively. Multivariate stepwise Logistic regression analysis suggestedthat HOMA index and severe OSAHS were independently correlated and the OR was 1.949(1.311～3.181)(P＜0.01).Conclusion:It wasconfumedfrom elderly snorers that there was a close association between OSAHS and MS, that IR might play an important role in thecoexistence of OSAHS and MS, and that the OSAHS patients with a lower SpO2 were more susceptible to IR
NETL
NSTL
维普
万方数据