Progress of research on the role ofAtoh1 gene in the regeneration of mammalian auditory hair cells
崔荣洁 1周诗玉 2李云龙 2梁程红 杨洋
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作者信息
1. 1昆明理工大学医学院附属医院，昆明 650032
2. 2云南省第一人民医院医学遗传科，昆明 650032
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摘要
Atoh1基因编码一种碱性螺旋-环-螺旋型(bHLH)转录因子，参与哺乳动物听觉毛细胞和支持细胞的产生与分化、调节耳蜗上皮细胞增殖，在感音神经性耳聋发病和恢复中具有重要作用。本文拟就Atoh1基因在听觉毛细胞再生中的最新研究进展进行阐述，以期为感音神经性耳聋的毛细胞再生基因疗法研究提供参考。 Atoh1 gene encodes a helix-loop-helix transcription factor which is involved in the generation and differentiation of mammalian auditory hair cells and supporting cells, and regulation of the proliferation of cochlear cells, therefore plays an important role in the pathogenesis and recovery of sensorineural deafness. This study reviews the progress of the Atoh1 gene in hair cell regeneration, with the aim of providing a reference for the study of hair cell regeneration gene therapy for sensorineural deafness.
Abstract
Atoh1 gene encodes a helix-loop-helix transcription factor which is involved in the generation and differentiation of mammalian auditory hair cells and supporting cells, and regulation of the proliferation of cochlear cells, therefore plays an important role in the pathogenesis and recovery of sensorineural deafness. This study reviews the progress of the Atoh1 gene in hair cell regeneration, with the aim of providing a reference for the study of hair cell regeneration gene therapy for sensorineural deafness.
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