Expert Consensus on the genetic diagnosis for Dystrophinopathies
娄桂予 1侯巧芳 1张玉薇 1祁娜 1余永国 2廖世秀 1李岭
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作者信息
1. 1河南省人民医院医学遗传研究所（郑州大学人民医院医学遗传研究所），郑州 450003
2. 2上海交通大学医学院附属新华医院儿童内分泌科，上海 200092
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摘要
Dystrophin基因的变异可导致X连锁隐性遗传的肌肉疾病，包括进行性杜兴(杜氏)肌营养不良(DMD)、贝克(贝氏)肌营养不良(BMD)和扩张型心肌病，严重威胁人类的生命和健康。遗传学诊断对于这类患者的诊断、治疗、预防具有十分重要的价值。如何合理选择、规范应用各项基因检测技术是临床医师必须掌握的技能。本共识经过同行专家的共同探讨，结合国内外经验和指南，从遗传学诊断角度，针对dystrophin基因检测技术的选择、检测策略、检测流程等方面提供指导性建议。 Dystrophinopathies, including Duchenne muscular dystrophy, Becker muscular dystrophy and dilated cardiomyopathy, are X-linked recessive genetic disorders due to variants of the dystrophin gene, which can seriously affect quality of life and health. Genetic diagnosis plays a crucial role in their diagnosis, treatment, and prevention. How to rationally select and standardize the use of various genetic techniques is a skill that clinicians must acquire. By compiling expertise of experts from the relevant areas and guidelines published home and abroad, this consensus has provided a guidance from the perspective of genetic diagnosis for the selection of genetic techniques, testing strategies, and detection process for dystrophinopathies.
Abstract
Dystrophinopathies, including Duchenne muscular dystrophy, Becker muscular dystrophy and dilated cardiomyopathy, are X-linked recessive genetic disorders due to variants of the dystrophin gene, which can seriously affect quality of life and health. Genetic diagnosis plays a crucial role in their diagnosis, treatment, and prevention. How to rationally select and standardize the use of various genetic techniques is a skill that clinicians must acquire. By compiling expertise of experts from the relevant areas and guidelines published home and abroad, this consensus has provided a guidance from the perspective of genetic diagnosis for the selection of genetic techniques, testing strategies, and detection process for dystrophinopathies.
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