Influence of thyroid function on the fetal fraction during second trimester of pregnancy
张宇琼 1乔龙威 2王挺 3李岭
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作者信息
1. 1南京医科大学附属苏州医院·苏州市立医院医学检验科，苏州 215002
2. 2南京医科大学附属苏州医院·苏州市立医院，姑苏学院，苏州 215002
3. 3南京医科大学附属苏州医院·苏州市立医院生殖与遗传中心，苏州 215002
折叠
摘要
目的 探讨孕中期甲状腺功能与胎儿游离DNA分数(FF)的相关性。 方法 将1 861例于2016年1月至2020年12月就诊于南京医科大学附属苏州医院·苏州市立医院的孕妇作为研究对象，在孕12 ~ 26周对其进行无创产前检测(NIPT)以及甲状腺素功能检测。用单变量分析和多变量回归模型评估其游离甲状腺素(FT4)水平与FF的相关性。 结果 单因素线性回归分析表明，FF随FT4水平的升高而升高(b ＝ 0.035，P<0.001)，中位数为10.78%(IQR：8.2%，13.82%)，随着FT4从≤ 12.0 pmol/L增高至FT4 > 16.0 pmol/L，FF的中位数分别为10.58%(IQR：7.86%，13.30%)至11.77%(IQR：8.64%，15.30%)。在进一步校正孕周和身体质量指数后，FF随着FT4水平的升高呈现增加的趋势，且具有显著的统计学意义(Ptrend < 0.001)。 结论 孕妇的游离甲状腺素水平可在一定程度上影响胎儿游离DNA分数。 Objective To assess the influence of thyroid function on the fetal fraction (FF) during the second trimester of pregnancy. Methods A total of 1 861 pregnant women undergoing non-invasive prenatal testing (NIPT) and thyroxine function testing at 12 ~ 26 gestational weeks at the Affiliated Suzhou Hospital of Nanjing Medical University/Suzhou Municipal Hospital from January 2016 to December 2020 were selected as the study subjects. Univariate analysis and multivariate regression models were used to assess the correlation between free thyroxine 4 (FT4) levels and FF. Results Univariate linear regression analysis indicated that the FF is correlated to the level of FT4 (b = 0.035, P<0.001). The median fetal FF was 10.78% (IQR: 8.2%, 13.82%), and this has increased along with the level of FT4 from 10.58% at ≤ 12.0 pmol/L to 11.77% at > 16.0 pmol/L. After further adjustment of gestational age and body mass index (BMI), the FF showed an increase trend along with the increase of FT4 levels, and a trend test also showed a statistical significance (Ptrend < 0.001). Conclusion Maternal FF can be affected by the level of free thyroxine during the second trimester of pregnancy.
Abstract
Objective To assess the influence of thyroid function on the fetal fraction (FF) during the second trimester of pregnancy. Methods A total of 1 861 pregnant women undergoing non-invasive prenatal testing (NIPT) and thyroxine function testing at 12 ~ 26 gestational weeks at the Affiliated Suzhou Hospital of Nanjing Medical University/Suzhou Municipal Hospital from January 2016 to December 2020 were selected as the study subjects. Univariate analysis and multivariate regression models were used to assess the correlation between free thyroxine 4 (FT4) levels and FF. Results Univariate linear regression analysis indicated that the FF is correlated to the level of FT4 (b = 0.035, P<0.001). The median fetal FF was 10.78% (IQR: 8.2%, 13.82%), and this has increased along with the level of FT4 from 10.58% at ≤ 12.0 pmol/L to 11.77% at > 16.0 pmol/L. After further adjustment of gestational age and body mass index (BMI), the FF showed an increase trend along with the increase of FT4 levels, and a trend test also showed a statistical significance (Ptrend < 0.001). Conclusion Maternal FF can be affected by the level of free thyroxine during the second trimester of pregnancy.
关键词
无创产前检测/胎儿游离DNA分数/游离甲状腺素/多变量线性回归模型
Key words
Non-invasive prenatal testing/Fetal fraction/Cell-free DNA/Free thyroxine 4/Multivariable linear regression model
万方数据