Studies on the association of genes with language disorders in the post-genomic era
王霞 1潘雪瑶 1李西 1姜孟 2许芯
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作者信息
1. 四川外国语大学英语学院/语言脑科学研究中心，重庆 400031
2. 四川外国语大学语言智能学院/语言脑科学研究中心，重庆 400031
折叠
摘要
遗传学研究进入后基因组时代以来，语言障碍的高遗传度已被证实。多种基因相关疾病均可能导致成人或儿童表现出不同程度的语言障碍。综述探讨了近十年来发现的较为常见的语言障碍疾病及其生物学机制，梳理了阅读障碍、额颞叶变性、特定型语言障碍、儿童言语失用症等与语言障碍密切相关的单一疾病的基因研究，以及对多种疾病共同的基因的探讨，以期揭示语言障碍的基因关联或致病机理，为语言障碍的预防及诊疗提供线索。 Since genetic research entered the post-genomic era, the high heritability of language disorders has been confirmed. A variety of genetic-related diseases may cause various types of language disorders in children and/or adults. This article has summarized language disorders and their underlying mechanisms by searching the Web of Science database over the last decade, and combed the genetic researches for dyslexia, frontotemporal degeneration, specific language disorder, childhood speech apraxia and other single diseases that are strongly associated with the language disorders. It also provided a discussion over the co-occurrence of multiple diseases, with an aim to revealing the genetic association and/or pathogenetic mechanism in order to provide inspiration for the prevention, diagnosis, and treatment of language disorders.
Abstract
Since genetic research entered the post-genomic era, the high heritability of language disorders has been confirmed. A variety of genetic-related diseases may cause various types of language disorders in children and/or adults. This article has summarized language disorders and their underlying mechanisms by searching the Web of Science database over the last decade, and combed the genetic researches for dyslexia, frontotemporal degeneration, specific language disorder, childhood speech apraxia and other single diseases that are strongly associated with the language disorders. It also provided a discussion over the co-occurrence of multiple diseases, with an aim to revealing the genetic association and/or pathogenetic mechanism in order to provide inspiration for the prevention, diagnosis, and treatment of language disorders.
关键词
阅读障碍/额颞叶变性/特定型语言障碍/儿童言语失用症/基因
Key words
Dyslexia/Frontotemporal degeneration/Specific language disorder/Childhood speech apraxia/Gene
万方数据