Effects of Xichuan Decoction in the Treatment of Patients with COPD at Stable Stage and Its Impact on CXCL13,TLR4 and Cytokines
Objective To investigate the effect of combined treatment with Xichuan decoction on patients with chron-ic obstructive pulmonary disease(COPD)at stable stage and its impact on chemokine CXC ligand 13(CXCL13),Toll-like receptor 4(TLR4)and cytokines.Methods A total of 128 patients with COPD at stable stage were selected from June 2020 to June 2022 and divided into two groups according to different treatment methods:observation group(n =64)and control group(n =64).Observation group was treated with Xichuan decoction combined with Indacatrolonium Bromide,while control group was treated with Indacatrolonium Bromide,and the course of treatment was 12 weeks.The clinical effect,pulmonary function before and after treatment,COPD assessment test(CAT)score,6-minute walking distance(6MWT),serum CXCL13,TLR4 and cytokine levels,and the occurrence of adverse reactions during treatment were compared between the two groups.Results After treatment,the total effective rate of observation group(93.75%,60/64)was higher than that of con-trol group(76.56%,49/64)(P<0.05).After treatment,the first second forced expiratory volume(FEV1),peak expira-tory flow(PEF),FEV1/forced vital capacity(FVC)and 6MWT in the two groups were higher or longer than those before treatment,while CAT scores and serum CXCL13,TLR4,tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)and inter-leukin-33(IL-33)were lower than those before treatment.FEV1,PEF,FEV1/FVC and 6MWT in observation group were higher or longer than those in control group,while CAT score,serum CXCL13,TLR4,TNF-α,IL-8 and IL-33 in observation group were lower than those in control group(P<0.05).During treatment,there was no significant difference in the inci-dence of adverse reactions between the two groups(P>0.05).Conclusion Combined treatment with Xichuan decoction for COPD patients at stable stage has a good effect,which can down-regulate the expression of serum CXCL13 and TLR4,and re-duce the levels of serum cytokines TNF-α,IL-8 and IL-33.
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