Value of Serum pro-BNP,Gal-3 and Hcy in Predicting Heart Failure with Preserved Ejection Fraction in Elderly Hypertensive Patients and Their Re-lationship with Cardiac Function Grade
Objective To investigate the correlation of serum brain natriuretic peptide precursor(pro-BNP),galac-tin-3(Gal-3)and homocysteine(Hcy)in elderly patients with hypertension,and to analyze the value of their combination in predicting herat failure with preserved ejection fraction(HFpEF)and its relationship with cardiac function classification.Methods From May 2018 to July 2021,208 elderly patients with hypertension were selected and divided into HEpEF group(n =52)and simple hypertension group(n =156)according to occurrence of HFpEF.Serum pro-BNP,Gal-3 and Hcy levels of the two groups were compared,and the relationship between the three indicators and their correlation with cardiac function classification was analyzed.The influence of the three indicators on the incidence risk of HEpEF was analyzed by hazard anal-ysis,and the value of the three in combination in predicting HEpEF was evaluated by receiver operating characteristic(ROC)curve.Results The serum levels of pro-BNP,Gal-3 and Hcy in HEpEF group were higher than those in simple hypertension group(P<0.01).Pearson correlation analysis showed that serum pro-BNP,Gal-3 and Hcy were positively correlated in sim-ple hypertension group and HEpEF group(P<0.01),and the correlation was higher in HEpEF group.Spearman correlation analysis showed that serum pro-BNP,Hcy and Gal-3 were positively correlated with NYHA classification(P<0.01).Multi-variate Logistic regression analysis showed that serum pro-BNP,Gal-3 and Hcy levels had independent effects on the risk of HFpEF(P<0.01).ROC curve analysis showed that the area under the curve(AUC)of serum pro-BNP,Hcy and Gal-3 in combination to predict the risk of HFpEF was 0.939(95%CI:0.898,0.968),the sensitivity was 0.885,and the specificity was 0.8333,which was better than the prediction of each index alone.Conclusion Serum pro-BNP,Gal-3 and Hcy levels in elderly hypertensive patients are significantly correlated,the three indicators are positively correlated with cardiac function classification,and abnormal elevation will increase the risk of HEpEF.The value of the three indicators in combination to pre-dict HFpEF is reliable.
Heart failureHypertensionElderlyBrain natriuretic peptide precursorHomocysteineGalectin-3CorrelationPrediction value
万方数据
维普
