Study on the Efficacy of Th17/Treg,Th1/Th2 Combined with NEWS2 Score in Predicting the Progression of Pneumonia
Objective To study the efficacy of Th17/Treg and Th1/Th2 combined with Nations Early Warning Score 2(NEWS2)in predicting the progression of pneumonia.Methods A total of 105 patients with pneumonia admitted from April 2020 to March 2023 were selected and divided into non-progression group and progression group according to the progres-sion of the disease.The Th17/Treg,Th1/Th2 and NEWS2 scores of the two groups were compared,and a multi-indicator combined prediction model for the progression of pneumonia was established by Logistic regression.Stata 10.0 software was used to determine the optimal threshold and the prediction accuracy of this location,and the receiver operating characteristic(ROC)curve was plotted.The area under the curve(AUC)was used to evaluate the effectiveness of covariates and joint pre-dictors to predict the progression of pneumonia.Results Th17/Treg and NEWS2 scores in the progression group were higher than those in the non-progression group,while Th1/Th2 was lower than that in the non-progression group(P<0.01).An in-crease inTh17/Treg and NEWS2 scores was an independent risk factor for the progression of pneumonia,and an increase in Th1/Th2 was an independent protective factor for the progression of pneumonia(P<0.01).The original covariate was fitted to generate a new joint predictor New-pre,with optimal critical value of 0.102,and the prediction accuracy of 97.00%.ROC curve showed that the AUC(0.916)of New-pre in predicting the progression of pneumonia was higher than Th17/Treg(0.704),Th1/Th2(0.747)and NEWS2 score(0.819)(P<0.05).Conclusion Th17/Treg and NEWS2 scores in-creased and Th1/Th2 scores decreased in patients with pneumonia progression.The combination of the three can be used as a quantitative scheme to predict individual disease progression,and can provide a reference for clinical treatment and assessment of disease progression.
PneumoniaTh17/TregTh1/Th2National early warning score 2Disease progressionPredictionRisk factorsReceiver operating characteristic curve
万方数据
维普
