Correlation between Serum Adipokine Irisin and Asprosin Levels and Os-teoporotic Hip Fracture in Elderly Men
Objective To investigate the relationship between serum levels of adipokine Irisin and Asprosin and os-teoporotic hip fracture in elderly men.Methods In total,106 elderly male patients with osteoporosis treated from June 2020 to June 2022 were selected as the case group,and 80 healthy elderly males who underwent physical examination during the same period were selected as the control group.Patients with osteoporosis were divided into the hip fracture group(n =44)and the non-hip fracture group(n =62)according to whether they had a hip fracture.Serum Irisin and Asprosin levels of all subjects were detected by enzyme-linked immunosorbent assay(ELISA).Bone density of the femoral greater trochoid,healthy femoral neck and the 1st-4th lumbar vertebra in patients with osteoporosis was measured by bone densitometer.Receiver oper-ating characteristic(ROC)curve was used to evaluate the predictive value of serum Irisin and Asprosin levels for osteoporotic hip fracture in elderly men.Multivariate Logistic regression analysis was used to explore the influencing factors of osteoporotic hip fracture in elderly men.Results The levels of serum Irisin and Asprosin in case group were higher than those in control group(P<0.01).The levels of serum Irisin and Asprosin in hip fracture group were higher than those in non-hip fracture group(P<0.01).The area under the ROC curve(AUC)of serum Irisin and Asprosin in combination in predicting hip frac-ture in elderly men with osteoporosis was 0.907(95%CI:0.862,0.952).Femoral neck bone mineral density≤0.77 g/cm2,serum Irisin≥140.26 ng/mL and serum Asprosin≥2.75 ng/mL were independent risk factors for hip frac-ture in elderly male patients with osteoporosis(P<0.01).Conclusion The increase of serum Irisin and Asprosin levels is a risk factor for hip fracture in elderly men with osteoporosis,and the combination of the two levels has important clinical value in predicting the incidence of osteoporotic hip fracture in elderly men.
OsteoporosisHip fractureElderlyMaleIrisinAsprosinBone mineral densityRisk factors
万方数据
维普
