首页|血清sTim-3和Galectin-9对重症急性肾损伤患者连续肾脏替代治疗短期预后的评估价值

血清sTim-3和Galectin-9对重症急性肾损伤患者连续肾脏替代治疗短期预后的评估价值

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目的 探讨血清可溶性T淋巴细胞免疫球蛋白黏蛋白分子-3(sTim-3)和半乳糖凝集素-9(Galectin-9)对重症急性肾损伤(AKI)患者连续肾脏替代治疗(CRRT)短期预后的评估价值.方法 选取2021 年3 月—2023 年3月收治的重症AKI 136 例作为研究对象.根据重症AKI患者CRRT开始90d内生存情况(短期预后),将病死患者纳入病死组(42 例),存活患者纳入生存组(94 例).采用受试者工作特征(ROC)曲线评估血清sTim-3 和Galectin-9 对重症AKI患者CRRT短期预后预测价值,采用多因素Logistic回归分析探讨重症AKI患者CRRT短期预后影响因素.结果 病死组血清sTim-3 和Galectin-9 均高于生存组(P<0.01);血清sTim-3 和Galectin-9 预测重症AKI患者CRRT短期预后的曲线下面积分别为0.762 和0.847,二者联合预测的曲线下面积为0.914.多因素Logistic回归分析显示,sTim-3≥17.00 ng/L、Galectin-9≥4.00 ng/L、急性生理与慢性健康状况评分系统Ⅱ评分≥20 分是重症AKI患者CRRT 90d病死的危险因素(P<0.05,P<0.01).结论 血清sTim-3 和Galectin-9 升高与重症AKI患者CRRT短期预后不良密切相关,可作为评估重症AKI患者CRRT短期预后不良的生物学指标,且二者联合预测效能更高.
Short-term Prognostic Value of Serum sTim-3 and Galectin-9 Levels in Continuous Renal Replacement Therapy in Patients with Severe Acute Kid-ney Injury
Objective To investigate the short-term prognostic value of serum soluble T lymphocyte immunoglobulin mucin-3(sTim-3)and Galectin-9(Galectin-9)in continuous kidney replacement therapy(CRRT)in patients with severe acute kidney injury(AKI).Methods In total,136 patients with severe AKI treated from March 2021 to March 2023 were selected as the research subjects.According to the survival of severe AKI patients within 90 days from CRRT(short-term prognosis),the patients who died were included in the death group(n =42),and the patients who survived were included in the survival group(n =94).The short-term prognostic value of serum sTim-3 and Galectin-9 in patients with severe AKI was evaluated by receiver operating characteristic(ROC)curve,and the factors affecting the short-term prognosis of CRRT in pa-tients with severe AKI were analyzed by multivariate Logistic regression analysis.Results The serum sTim-3 and Galectin-9 in death group were higher than those in survival group(P<0.01).The area under the curve(AUC)of serum sTim-3 and Galectin-9 in predicting the short-term prognosis of CRRT in patients with severe AKI was 0.762 and 0.847,respectively,and the AUC of the combined prediction was 0.914.Multivariate Logistic regression analysis showed that sTim-3≥17.00 ng/L,Galectin-9≥4.00 ng/L,Acute physiological and Chronic health status score system Ⅱ≥20 scores were the risk factors for death within 90 days from CRRT in patients with severe AKI(P<0.05,P<0.01).Conclusion The in-crease of serum sTim-3 and Galectin-9 is closely related to the poor short-term prognosis of CRRT in patients with severe AKI,which can be used as a biological indicator to evaluate the poor short-term prognosis of CRRT in patients with severe AKI,and the combination of the two has higher predictive performance.

Acute Kidney InjurySevereContinuous renal replacement therapySoluble T lymphocyte immunoglob-ulin mucin-3Galectin-9PrognosisReceiver operating characteristic curveLogistic regression analysis

唐冰冰、张毳毳、刘峰、魏桦楠、吕富荣

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710000 西安,空军军医大学第二附属医院(唐都医院)急诊科

710000 西安,西安国际医学中心医院麻醉舒适化医疗中心

710000 西安,西安市第三医院重症医学科

710000 西安,西安市中医医院脑病科一病区

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急性肾损伤 重症 连续肾脏替代治疗 可溶性T淋巴细胞免疫球蛋白黏蛋白分子-3 半乳糖凝集素-9 预后 受试者工作特征曲线 Logistic回归分析

陕西省中医药局科研项目

2019-ZzjC035

2024

10.3969/j.issn.2095-3097.2024.01.016

转化医学杂志
海军总医院

转化医学杂志

CSTPCD
影响因子：0.671
ISSN：2095-3097
年,卷(期)：2024.13(1)
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