首页|胃癌患者血清及组织中IL-17、Hcy表达水平与微卫星状态的关系

胃癌患者血清及组织中IL-17、Hcy表达水平与微卫星状态的关系

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目的 探究胃癌患者血清及组织中白细胞介素-17(IL-17)、同型半胱氨酸(Hcy)表达水平与微卫星状态的关系.方法 选取2020 年3 月—2022 年3 月就诊的40 例肿瘤微卫星稳定和低度微卫星不稳定胃癌患者作为稳定组,另选择同期40 例肿瘤高度微卫星不稳定胃癌患者作为不稳定组.收集2 组一般资料,检测患者血清IL-17、Hcy水平及术中切除标本IL-17 表达水平,胃癌患者微卫星状态的危险因素采用多因素Logistic回归分析,并采用受试者工作特征(ROC)曲线分析胃癌患者血清IL-17、Hcy及组织IL-17 水平对微卫星状态的预测价值.结果 不稳定组淋巴转移例数少于稳定组(P<0.05).不稳定组血清及组织IL-17、Hcy水平均低于稳定组(P<0.05,P<0.01).多因素Logistic回归分析显示,淋巴转移、血清IL-17、血清Hcy、组织IL-17 水平均是影响胃癌患者微卫星状态的危险因素(P<0.05,P<0.01).ROC曲线分析显示,血清IL-17、Hcy水平及组织中IL-17 水平联合预测胃癌患者微卫星状态的曲线下面积及敏感度、特异度均高于单一指标预测.结论 淋巴转移、血清及组织中IL-17、Hcy水平是影响胃癌患者微卫星状态的危险因素,淋巴转移、血清及组织中IL-17、Hcy联合检测可较好地预测胃癌患者的微卫星状态.
Relationship Between IL-17 and Hcy Expression Levels and Microsatellite Status in Serum and Tissue of Patients with Gastric Cancer
Objective To investigate the relationship between the expression levels of interleukin-17(IL-17)and homocysteine(Hcy)and microsatellite status in serum and tissues of patients with gastric cancer.Methods A total of 40 pa-tients with microsatellite stable and low-grade microsatellite unstable gastric cancer treated from March 2020 to March 2022 were selected as the stable group,and another 40 patients with high-grade microsatellite unstable gastric cancer were selected as the unstable group.General data in the two groups were collected,and serum IL-17,Hcy levels,and IL-17 expression lev-els in dissected specimens during the operation were detected.The risk factors of microsatellite status in patients with gastric cancer were analyzed by multivariate Logistic regression analysis.The predictive value of serum IL-17,Hcy and IL-17 levels in the tissue on microsatellite status in patients with gastric cancer was analyzed by receiver operating characteristic(ROC)curve.Results The number of lymphatic metastasis in the unstable group was smaller than that in the stable group(P<0.05).The IL-17 and Hcy levels in serum and tissues in unstable group were lower than those in stable group(P<0.05,P<0.01).Multivariate Logistic regression analysis showed that lymphatic metastasis,serum IL-17,serum Hcy and IL-17 levels in the tissue were all risk factors affecting microsatellite status in patients with gastric cancer(P<0.05,P<0.01).ROC curve analysis showed that the area under the curve,sensitivity and specificity of serum IL-17 and Hcy levels and IL-17 levels in tissue in combination in predicting microsatellite status in patients with gastric cancer were higher than that predicted by single index.Conclusion Lymphatic metastasis,and IL-17 and Hcy levels in serum and tissue are risk factors affecting microsatellite status in patients with gastric cancer,and the combined detection of lymphatic metastasis,and IL-17 and Hcy levels in serum and tissue can better predict microsatellite status in patients with gastric cancer.

Stomach neoplasmsInterleukin-17HomocysteineMicrosatellite stateReceiver operating characteris-tic curveAnalysis of influencing factorsDiagnostic effectivenessArea under the curve

徐爱芳、刘征、宫向良、李世龙、宋扬

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063000 河北唐山,唐山市人民医院检验科

063000 河北唐山,唐山市中心医院腔镜外科

胃肿瘤 白细胞介素-17 同型半胱氨酸 微卫星状态 受试者工作特征曲线 影响因素分析 诊断效能 曲线下面积

河北省医学科学研究重点课题(2018)

20181244

2024

10.3969/j.issn.2095-3097.2024.01.020

转化医学杂志
海军总医院

转化医学杂志

CSTPCD
影响因子：0.671
ISSN：2095-3097
年,卷(期)：2024.13(1)
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