Differential Expression of B7-H6 in Cervical Intraepithelial Neoplasia and Cervical Cancer Tissues and Its Correlation with Tumor Infiltrating T Lymphocytes and Prognosis
Objective To explore the correlation of cervical intraepithelial neoplasia and differential expression of B7 homologous 6(B7-H6)with tumor infiltrating T lymphocytes and prognosis.Methods Sixty surgical patients diagnosed with cervical cancer by pathological examination from June 2019 to March 2021 were selected as the research group,and 60 pa-tients with cervical intraepithelial neoplasia in the same age group during the same period were selected as the control group.B7-H6 expression(H-score)in the tissue and serum B7-H6 levels were compared between the two groups,and H-score and serum B7-H6 levels of patients with different degrees of tumor infiltration of tumor infiltrating T lymphocytes were compared be-tween the research group with tumor infiltration.The correlation between H-score,serum B7-H6 level and the degree of tumor infiltration of T lymphocytes was analyzed.The research group was followed up for 1 year after surgery.General data,H-score score and serum B7-H6 level of patients with different prognosis were compared to explore the influencing factors of prognosis,and the value of H-score score and serum B7-H6 level before surgery in predicting prognosis of patients was analyzed.Results H-score and serum B7-H6 levels in the research group were higher than those in the control group(P<0.01).In the re-search group,the H-score and serum B7-H6 levels of infiltration grade 0 patients with tumor infiltrating T-lymphocyte were higher than those of grade 1 and grade 2 patients,and higher in grade 1 patients than in grade 2 patients(P<0.05).H-score and serum B7-H6 levels were negatively correlated with the degree of tumor infiltration of tumor infiltrating T lymphocytes in the research group(P<0.01).Multivariate logistic regression analysis showed that tumor diameter,Federation International of Gynecology and Obstetrics(FIGO)stage,lymph node metastasis,depth of interstitial infiltration,H-score and serum B7-H6 level were all independent risk factors for poor prognosis in patients undergoing cervical cancer surgery(P<0.01).The area under the curve(AUC)of tumor diameter,FIGO stage,lymph node metastasis,depth of interstitial infiltration,H-score and serum B7-H6 levels for predicting poor prognosis of patients undergoing cervical cancer surgery was 0.736,0.726,0.714,0.712,0.842 and 0.840,respectively.The AUC of H-score and serum B7-H6 levels in prediction was higher than that of tumor diameter,FIGO stage,lymph node metastasis and interstitial infiltration depth(P<0.05).H-score and serum B7-H6 levels had good clinical efficacy in predicting the poor prognosis of patients undergoing cervical cancer surgery.Con-clusion The expression of B7-H6 in cervical cancer tissue is higher than that of cervical intraepithelial neoplasia,and the ex-pression of B7-H6 in cervical cancer tissue and the level of serum B7-H6 are negatively correlated with the degree of tumor in-filtration of tumor infiltrating T lymphocytes,which is also an independent risk factor for poor prognosis in patients undergoing cervical cancer surgery,and has certain clinical value in predicting prognosis.
万方数据
维普
