首页|促血管生成因子在支气管肺发育不良中的研究进展

促血管生成因子在支气管肺发育不良中的研究进展

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随着医疗技术的不断进步,极早产儿存活率不断提高,支气管肺发育不良的发生率也随之升高.肺血管生成受损、肺泡发育停滞、细胞外基质改变是支气管肺发育不良的主要特征.促血管生成因子水平变化对维持正常肺血管生成及肺泡发育具有关键作用,如血管内皮生长因子、血管生成素、血小板源性生长因子、肝细胞生长因子等.上述促血管生成因子均与支气管肺发育不良密切相关,在该病的临床防治中具有良好的发展前景.
Research Progress on Pro-angiogenic Factors in Bronchopulmonary Dyspla-sia
With the continuous progress of medical technology,the survival rate of extremely preterm infants has been increasing,and the incidence of bronchopulmonary dysplasia has also increased.The main characteristics of bronchopulmonary dysplasia are impaired pulmonary angiogenesis,alveolar arrest and extracellular matrix change.Changes in the levels of pro-angiogenic factors,such as vascular endothelial growth factor,angiopoietin,platelet-derived growth factor,and hepatocyte growth factor,play a key role in maintaining normal pulmonary angiogenesis and alveolar development.These factors are close-ly associated with the development of bronchopulmonary dysplasia and have a good prospect in the clinical prevention and treat-ment of the disease.

Bronchopulmonary dysplasiaPreterm infantVascular endothelial growth factorAngiogeninPlatelet-derived growth factorTransforming growth factor-βHepatocyte growth factorHypoxia-inducible factorReview

刘莹、赵旭晶

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044000 山西运城,山西医科大学附属运城医院新生儿科

044000 山西运城,运城市妇幼保健院新生儿科

支气管肺发育不良 早产儿 血管内皮生长因子 血管生成素 血小板源性生长因子 转化生长因子-β 肝细胞生长因子 缺氧诱导因子 综述

山西省卫生健康委科研项目

2020166

2024

10.3969/j.issn.2095-3097.2024.01.026

转化医学杂志
海军总医院

转化医学杂志

CSTPCD
影响因子：0.671
ISSN：2095-3097
年,卷(期)：2024.13(1)
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