Effect of Intense Pulsed Light Combined with Dextran 70 and Glycerol Eye Drops in the Treatment of Moderate-to-Severe Xerophthalmia
Objective To explore the effect of intense pulsed light(IPL)combined with dextran 70 and glycerol eye drops in the treatment of moderate-to-severe xerophthalmia.Methods In total,124 patients with xerophthalmia admitted from April 2021 to March 2023 were selected,and treated with dextran 70 and glycerol eye drops.On this basis,IPL treat-ment was performed on the day of treatment,and at 1,3,and 7 weeks after treatment.The stability of tear film,ocular sur-face condition,meibomian gland function,visual quality,clinical efficacy at different time points,and incidence of adverse reactions were compared among patients.Results Compared with that on the day of treatment,there was a significant in-crease in break-up time(BUT),Schirmer's I test,and Strehl ratio,and a significant reduction in Ocular Surface Disease In-dex(OSDI),Fluorescein Corneal Staining,Meibomian Gland Yielding Secretion Score(MGYSS)and Objective Scatter Index in all patients at weeks 1,3,and 7(P<0.05).Patients reported a higher BUT at weeks 3 and 7 than at week 1,a lower OSDI at week 7 than at weeks 1 and 3,and a lower MGYSS scores at weeks 3 and 7 than at week 1(P<0.05).Compared with that on the day of treatment(98/124,79.03%),the total effective rate of patients increased(P<0.05)at weeks 1,3,and 7 after treatment(110/124,88.71%;113/124,91.13%;115/124,92.74%).No statistical difference was found in the adverse reaction rate on the day of treatment,and at weeks 1,3,and 7 after treatment(P>0.05).Conclusion IPL combined with dextran 70 and glycerol eye drops are effective in the treatment of moderate-to-severe xerophthalmia,which can effectively improve tear film stability,ocular surface integrity,meibomian gland,and visual quality.
Intense pulsed lightDextran 70 and glycerol eye dropsXerophthalmiaBreak-up timeSchirmer's I testOcular surface disease indexMeibomian gland yielding secretion scoreStrehl ratio
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维普
