Efficacy and Safety of Edaravone Dexborneol Combined with Bu-tylphthalide in the Treatment of Patients with Acute Ischemic Stroke and Type 2 Diabetes Mellitus
Objective To explore the efficacy and safety of Edaravone Dexborneol combined with Butylphthalide in the treatment of acute ischemic stroke(AIS)complicated with type 2 diabetes mellitus(T2DM).Methods A total of 123 patients with AIS complicated with T2DM treated from July 2019 to July 2023 were selected and divided into two groups ran-domly.On the basis of conventional treatment,the control group(n =61)was treated with Edaravone Dexborneol,and the observation group(n =62)was supplemented with Butylphthalide.The clinical efficacy and occurrence of adverse reactions were compared between the two groups.Modified Rankin Scale(mRS)score,National Institutes of Health Stroke Scale(NIHSS)score,Control Status Scale for Diabetes(CSSD70),blood lipids[high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),triglyceride(TG),,total cholesterol(TC)]and serum enzyme-related indexes[creatine kinase(CK),lactate dehydrogenase(LDH)]before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 96.77%(60/62),which was higher than that of the control group[81.97%(50/61)](P<0.05).After treatment,mRS and NIHSS scores as well as LDL-C and CK levels in the ob-servation group were lower than those in the control group,while the CSSD70 scores and HDL-C levels were higher than those in the control group(P<0.05).The changes of the above indexes before and after treatment in observation group were higher than those in control group(P<0.05).After treatment,there was no significant difference in TG,TC,LDH levels as well as total incidence of adverse reactions between the two groups(P>0.05).Conclusion Butylphthalide combined with Edara-vone Dexborneol has a high curative effect on AIS complicated with T2DM,which can effectively alleviate the clinical symp-toms of patients on the basis of ensuring safety.
Acute ischemic strokeType 2 diabetes mellitusEdaravone DexborneolButylphthalideNational Insti-tutes of Health Stroke ScaleModified Rankin ScaleCreatine kinaseLactate dehydrogenase
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