The Relationship Between Serum Levels of sICAM-1 and CysC and the Efficacy of Antiplatelet Therapy in Patients with Ischemic Stroke Complicated by Cerebral Microbleeds
Objective To explore the relationship between serum soluble intercellular adhesion molecule-1 ( sICAM-1 ) and cystatin C ( CysC ) and the efficacy of antiplatelet therapy in patients with ischemic stroke complicated by cerebral microhemorrhage.Methods A retrospective analysis was performed on the medical records of 90 patients with ischemic stroke complicated by cerebral microhemorrhage,who were admitted to Wujin Hospital of Traditional Chinese Medicine from June 2018 to December 2019.Based on the outcomes of antiplatelet treatment,the patients were divided into a good prognosis group ( 66 cases ) and a poor prognosis group ( 24 cases ) .The serum levels of sICAM-1 and CysC were compared between the two groups,and the correlation between serum sICAM-1 and CysC levels and the severity of cerebral microhemorrhage was analyzed.The predictive value of serum sICAM-1 and CysC for the efficacy of antiplatelet therapy in these patients was also assessed.Results The levels of serum sICAM-1 and CysC were higher in the poor prognosis group than in the good prognosis group ( P<0.05 ) .In the severe,moderate,and mild groups,the serum levels of sICAM-1 and CysC decreased sequentially,and the differences among these groups were statistically significant ( P<0.05 ) .Spearman correlation analysis revealed that serum sICAM-1 and CysC levels were positively correlated with the severity of cerebral microhemorrhage ( P<0.05 ) .Receiver operating characteristic ( ROC ) curve analysis indicated that the areas under the curve ( AUC ) for serum sICAM-1,CysC,and their combination in predicting the efficacy of antiplatelet therapy were 0.772,0.779,and 0.873,respectively.Conclusion Serum sICAM-1 and CysC levels are positively correlated with the severity of cerebral microhemorrhage in patients with ischemic stroke,and these biomarkers can be used to predict the efficacy of antiplatelet therapy.
Cerebral ischemic strokeCerebral microhemorrhageSoluble intercellular adhesion molecule-1Cystatin CAntiplatelet therapyROC curveArea under the curveData correlation
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维普
