Impact of Thrombolytic Therapy on Serum lncRNA CAI2,UA,Hcy Levels,Cerebral Blood Flow Perfusion,and Neurological Recovery in Patients with Acute Cerebral Infarction
Objective To explore the changes in serum long non-coding RNA CAI2 ( LncRNA CAI2 ),uric acid ( UA ),homocysteine ( Hcy ) levels,cerebral blood flow perfusion,and neurological function following thrombolytic therapy for acute cerebral infarction.Methods 85 patients with acute cerebral infarction who underwent treatment at Fuyang Cancer Hospital from August 2020 to March 2023 were selected as the study subjects.According to the treatment plan,the patients were divided into two groups,and 40 patients receiving conventional treatment were included in the control group.The clinical efficacy,serum LncRNA CAI2,UA,Hcy levels,cerebral blood flow perfusion indicators,neurological function recovery,cerebral blood flow parameters,and the incidence of postoperative adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in the thrombolysis group was 97.78％ ( 44/45 ),which was higher than 82.50％ ( 33/40 ) in the control group ( P<0.05 ) .After treatment,the levels of LncRNA CAI2 and Hcy decreased in both groups,while the levels of UA increased.The changes in the thrombolysis group were more significant ( P<0.05 ) .After treatment,both groups showed an increase in rCBV and rCBF,a decrease in MTT,and more significant changes in the thrombolysis group ( P<0.05 ) .After treatment,both groups showed a decrease in NIHSS scores and an increase in MMSE scores,with more significant changes observed in the thrombolysis group ( P<0.05 ) .After treatment,both RI and PI decreased,while Vm increased in both groups,and the changes in the thrombolysis group were more significant ( P<0.05 ) .There was no statistical difference in the incidence of adverse reactions such as elevated transaminases,rash,vomiting,nausea,and renal function damage between the two groups ( P>0.05 ) .Conclusion Intraveno us thrombolysis can effectively improve the treatment effectiveness of patients with acute cerebral infarction,optimize serum levels of LncRNA CAI2,UA,and Hcy,and improve cerebral blood supply.In addition,the recovery of neurological function is good and does not pose an additional burden on patients.
万方数据
维普
