Diagnostic Value of Serum ACE and Complement C1q in Type 2 Diabetes Mellitus Complicated with Arteriosclerosis and Occlusion of Lower Limbs
Objective To investigate the diagnostic value of serum angiotensin-converting enzyme ( ACE ) and complement C1q in patients with type 2 diabetes mellitus ( T2DM ) complicated with lower extremity arteriosclerosis and cclusion ( ASO ) .Methods 122 patients with T2DM who were treated at Shijingshan Teaching Hospital of Capital Medical University from February 2022 to September 2023 were selected as the study subjects.They were divided into an uncomplicated ASO group of 82 cases and a combined ASO group of 40 cases based on whether they had ASO.Clinical data were collected from all patients,and the serum ACE and complement C1q levels between the two groups were compared.The receiver operating characteristic ( ROC ) curve was used to evaluate the diagnostic value of serum ACE and complement C1q for ASO in T2DM patients.Multivariate logistic regression analysis was performed to explore the influencing factors of ASO in T2DM patients.Results The levels of serum ACE and complement C1q in patients with concurrent ASO were higher than those in patients without ASO ( all P<0.05 ) .The AUC of serum ACE and complement C1q in T2DM cases with ASO was 0.817 ( 95％CI:0.772～0.862 ) and 0.739 ( 95％CI:0.691～0.784 ),respectively,and the AUC of serum ACE and complement C1q for T2DM patients with ASO was 0.908 ( 95％CI:0.863～0.954 ) .The proportion of fasting blood glucose level,LDL-C level,HbA1c level,and diabetic peripheral neuropathy in the ASO group were higher than those in the non-ASO group ( all P<0.05 ) .Diabetic peripheral neuropathy ( OR=2.782,95％CI:1.290～5.997 ),serum ACE ≥ 46.02 U/L ( OR=4.651,95％CI:2.115～10.226 ),serum complement C1q ≥ 181.24 mg/L ( OR=3.557,95％CI:1.753～7.218 ) were the influential factors for ASO in T2DM cases ( all P<0.05 ) .Conclusion The levels of serum ACE and complement C1q are significantly elevated in patients with T2DM combined with ASO.These two indicators can serve as potential biological markers for diagnosing ASO in T2DM patients,and their combined use is more effective.
Angiotensin-converting enzymeComplement C1qType 2 diabetesArteriosclerosis and occlusion of lower limb
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维普
