The Clinical Significance of TB-IGRA,GeneXpert Combined with T Cell Monitoring for Tumor Patients with Concurrent Tuberculosis Infection
Objective To evaluate the combined application of γ-interferon release detection technology ( TB-IGRA ),real-time fluorescence quantitative nucleic acid amplification detection technology ( GeneXpert ),and T cell monitoring strategy in cancer patients with concurrent tuberculosis infection,and investigate its diagnostic ability.Methods A retrospective analysis was conducted for 100 cancer patients who were admitted to The People's Hospital of Rugao from Sep.2023 to Jun.2024.They were divided into co-infection group ( 23 cases ) and tumor-only group ( 77 cases ) based on whether they were co-infected with tuberculosis.Clinical data for all patients were analyzed,and the positive rates of TB-IGRA,GeneXpert,and T cell monitoring for all tumor patients were calculated,and their detection capabilities were compared.Results Clinical bacteriological examination confirmed that there were 23 cases ( 23％ ) of tumor patients with combined tuberculosis infection and 77 cases ( 77％ ) of uninfected patients.There were no statistically significant differences between infected and uninfected patients in terms of gender ratio,age distribution,and tumor classification ( P>0.05 ) .The positive rate of TB-IGRA was 65.22％ ( 15/23 ),the nucleic acid amplification test was 47.83％ ( 11/23 ),and the T-cell monitoring of tuberculosis infection was 55.52％ ( 13/23 ) .When the three testing techniques were applied in combination,the positive detection rate of tuberculosis bacteria was 82.61％ ( 19/23 ),which was significantly higher than that of single detection ( P<005 ) .Conclusion The TB-IGRA assay had the highest positive rate of detecting patients with tumor-combined tuberculosis infection,and the combined use of the three assays had a significantly higher positive detection rate than that of individual application,which has good clinical application value.
T cell immune spot testTB-IGRAGeneXpertT cell monitoringTumorTuberculosis infection
万方数据
维普
