Effect of Minimally Invasive Pulmonary Surfactant Therapy on Respiratory Distress Syndrome in Premature Infants and Its Impact on Arterial Blood Gas Analysis
Objective To analyze the effect of minimally invasive pulmonary surfactant therapy ( LISA ) on respiratory distress syndrome ( RDS ) in premature infants and its impact on arterial blood gas analysis indices.Methods 148 premature infants with RDS admitted to the Department of Neonatal Intensive Care Medicine of Shanxi Children' s Hospital from June 2022 to June 2023 were randomly divided into the routine administration group and the minimally invasive administration group,with 74 cases in each group.The minimally invasive administration group received LISA treatment,while the conventional administration group was treated with the standard method.The treatment conditions,arterial blood gas analysis indices before and after treatment,and the occurrence of complications during hospitalization were observed.Results Compared with the routine administration group,the minimally invasive administration group showed a significantly lower rate of invasive mechanical ventilation and re-administration of pulmonary surfactant within 72 hours ( P<0.05 ),as well as shorter duration of non-invasive ventilation and shorter hospitalization time ( P<0.05 ) .After treatment,both groups showed increased arterial partial pressure of oxygen ( PaO2 ) and PH,with the minimally invasive group showing higher values than the conventional group ( P<0.05 ) .Both groups showed a decrease in arterial partial pressure of carbon dioxide ( PaCO2 ),with the minimally invasive group having lower values than the conventional group ( P<0.05 ) .Additionally,the incidence of bronchopulmonary dysplasia in the minimally invasive group was lower than in the conventional group ( P<0.05 ) .Conclusion LISA treatment for premature infants with RDS can improve treatment outcomes,enhance arterial blood gas indices,and reduce the risk of complications.
Premature infantsRespiratory distress syndromeMinimally invasivePulmonary surfactantBlood Gas AnalysisComparative study on efficacy
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