Assessment Value of Serum ChE and Syndecan-1 Levels in Patients with AECOPD Complicated with Ventilator-Associated Pneumonia on Disease Severity and Prognosis
Objective To investigate the value of serum cholinesterase ( ChE ) and Syndecan-1 levels in assessing the condition and prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD ) combined with ventilator-associated pneumonia ( VAP ) .Methods A total of 132 patients with AECOPD combined with VAP were selected and divided into the low-risk VAP group ( 42 cases ),the medium-risk VAP group ( 44 cases ),and the high-risk VAP group ( 46 cases ) based on their acute physiological and chronic health evaluation Ⅱ( APACHE Ⅱ) scores.Additionally,the patients were categorized into the death group ( 52 cases ) and the survival group ( 80 cases ) according to their 28-day prognosis.Serum ChE and Syndecan-1 levels were measured using enzyme-linked immunosorbent assay ( ELISA ) .Results Serum ChE levels decreased sequentially,while Syndecan-1 levels increased sequentially,in the low-risk,medium-risk,and high-risk VAP groups ( P<0.05 ) .The APACHE Ⅱ scores of patients with AECOPD combined with VAP were negatively correlated with serum ChE levels and positively correlated with serum Syndecan-1 levels ( P<0.05 ) .The serum ChE level in the death group was lower than that in the survival group,whereas the Syndecan-1 level was higher,with a statistically significant difference ( P<0.05 ) .The area under the curve ( AUC ) for assessing poor prognosis in patients with AECOPD combined with VAP,when considering serum ChE combined with Syndecan-1 levels,was greater than that when considering serum ChE or Syndecan-1 levels alone ( P<0.05 ) .Conclusion Decreased serum ChE levels and increased Syndecan-1 levels were associated with disease exacerbation and poor prognosis in patients with AECOPD combined with VAP.The combined assessment of serum ChE and Syndecan-1 levels was of high value in predicting the prognosis of these patients.
Chronic Obstructive Pulmonary Disease ( COPD )Ventilator-Associated Pneumonia ( VAP )CholinesteraseSyndecan-1PrognosisData CorrelationROC CurveArea Under the Curve ( AUC )
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