Relationship Between Serum CHI3L1 Levels and Metabolism-Related Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
Objective To investigate the relationship between serum chitinase 3-like 1 ( CHI3L1 ) levels and metabolism-associated fatty liver disease ( MAFLD ) in patients with type 2 diabetes mellitus ( T2DM ) .Methods 120 T2DM patients with MAFLD ( MAFLD group ) and 120 T2DM patients without MAFLD ( non-MAFLD group ) were selected according to a 1︰1 ratio.Serum CHI3L1 levels were detected by enzyme-linked immunosorbent assay.A multiple-factor conditional logistic regression model was used to analyze the relationship between CHI3L1 and MAFLD in T2DM patients and to draw receiver operating characteristic ( ROC ) curves.Results Serum CHI3L1 levels were elevated in the MAFLD group compared with the non-MAFLD group ( P<0.05 ) .After adjusting for confounders,elevated CHI3L1 was an independent risk factor for concurrent MAFLD in T2DM patients ( P<0.05 ) .The area under the curve ( AUC ) of serum CHI3L1 level for predicting concurrent MAFLD in T2DM patients was 0.803 ( 95％ CI:0.747-0.851 ),with a sensitivity of 70.83％ and a specificity of 88.33％.Conclusion Elevated serum CHI3L1 levels in T2DM patients are an independent risk factor for concurrent MAFLD and have predictive value for T2DM patients with MAFLD complications.
Type 2 diabetes mellitusMetabolically associated fatty liver diseaseChitinase 3-like 1Logistic modelROC curveArea under the curve
万方数据
维普
