Correlation Between Th22 Cells,IL-22 Levels,and Disease Severity in Patients with Ulcerative Colitis
Objective To investigate the expression levels and clinical significance of Th22 cell subsets and interleukin-22 ( IL-22 ) in patients with ulcerative colitis ( UC ) .Methods A total of 106 UC patients who underwent colonoscopy at Nanhu Hospital between June 2020 and December 2023 were enrolled,including 51 patients in the mild UC group,34 in the moderate UC group,and 21 in the severe UC group.Additionally,50 healthy individuals who underwent physical examinations at our hospital during the same period were selected as the control group.The proportions of Th22 cell subsets,as well as serum levels of IL-22,C-reactive protein ( CRP ),and erythrocyte sedimentation rate ( ESR ),were compared among the groups.Results The proportions of Th22 cells and the levels of IL-22,CRP,and ESR in the peripheral blood of UC patients were significantly higher than those in the control group.With the aggravation of UC,the proportions of Th22 cells and the levels of IL-22,CRP,and ESR showed an increasing trend ( P<0.05 ) .The results of Spearman correlation analysis showed that Th22 subsets and IL-22 levels were positively correlated with disease severity,CRP,and ESR ( P<0.05 ) .Conclusion The levels of Th22 subsets and IL-22 in the peripheral blood of UC patients were increased,which was closely related to disease activity.
万方数据
维普
