Predictive Value of Serum RBP4 Combined with Systemic Immune-Inflammation Index for Major Adverse Cardiovascular Events After Intervention in Patients with Acute Coronary Syndrome
Objective To investigate the predictive value of serum retinol-binding protein 4 ( RBP4 ) combined with the systemic immunoinflammatory index ( SII) for major adverse cardiovascular events ( MACE ) after intervention in patients with acute coronary syndrome ( ACS ) .Methods A total of 152 patients with ACS who underwent intervention at Yunyang County People's Hospital between March 2021 and October 2023 ( ACS group ) were enrolled and divided into the MACE group ( 32 patients ) and non-MACE group ( 120 patients ) based on the occurrence of MACE within 6 months after intervention.Additionally,57 healthy volunteers who underwent health checkups during the same period were selected as the control group.Clinical data of the ACS patients were collected,serum RBP4 levels were measured,and the SII was calculated.Factors associated with post-interventional MACE in ACS patients and the predictive value of serum RBP4 and SII were analyzed.Results Serum RBP4 levels and SII were significantly higher in the ACS group compared to the control group ( P<0.05 ) .Increased age,acute myocardial infarction,KILLIP classification ≥ class Ⅱ,elevated RBP4,and elevated SII were identified as independent risk factors for MACE after intervention in patients with ACS ( P<0.05 ) .Conversely,an elevated left ventricular ejection fraction was an independent protective factor against MACE ( P<0.05 ) .The area under the curve ( AUC ) for predicting post-interventional MACE in ACS patients based on serum RBP4 levels combined with SII was 0.833,which was higher than the AUCs of 0.744 and 0.750 predicted by RBP4 and SII alone,respectively ( P<0.05 ) .Conclusion Serum RBP4 levels combined with SII exhibited high value in predicting MACE after intervention in ACS patients and had certain guiding significance for prognosis assessment.
acute coronary syndromepercutaneous coronary interventionretinol-binding protein 4systemic immune-inflammation indexadverse cardiovascular eventsROC curvearea under the curve
万方数据
维普
