Expression and Clinical Significance of HR-HPV Load and Regulatory T Lymphocytes in Patients with Cervical Lesions
Objective To investigate the differences in high-risk human papillomavirus ( HR-HPV ) load and regulatory T lymphocyte ( Treg ) expression among patients with different cervical lesions.Methods A total of 200 patients with HR-HPV persistent infection were divided into cervical intraepithelial neoplasia ( CIN ) group,cervical cancer group,and chronic cervicitis group.HPV-DNA in cervical secretions and Treg cells were detected and compared among the three groups.Results There were significant differences in the positive rate of HR-HPV infection,HR-HPV load,and Treg cells among the chronic cervicitis group,CIN grade Ⅰ group,CIN grade Ⅱ group,CIN grade Ⅲ group,and cervical cancer group ( P<0.05 ) .There was a significant difference in the proportion of Treg cells between different HR-HPV load groups in CIN grade Ⅲ and cervical cancer patients ( all P<0.05 ) .Treg cells were positively correlated with HR-HPV load in patients with CIN grade Ⅲ and cervical cancer ( all P<0.05 ) .Conclusion The viral load of HR-HPV is related to the degree of cervical lesions,and Treg cells in the cervical microenvironment and the viral load of HR-HPV jointly participate in the occurrence and development of cervical lesions.
Cervical lesionsRegulatory T cellsHigh-risk human papillomavirusDNA detectionData correlation
万方数据
维普
