Clinical Observation of Radiotherapy Combined with Chemotherapy in Treatment of Liver Cancer Patients with Portal Vein Thrombosis
Objective To explore the therapeutic effect of radiotherapy combined with chemotherapy on liver cancer patients with portal vein thrombosis.Methods 100 patients with liver cancer complicated with portal vein cancer thrombus who were treated at Heilongjiang Provincial Infectious Disease Prevention and Control Hospital from December 2021 to December 2023 were included in this study.The patients were randomly divided into the observation group and the control group,with 50 patients in each group.The control group received conventional radiation therapy,while the observation group received radiation therapy combined with the FOLFOX4 strategy on the basis of the control group.The efficacy of combination therapy and radiotherapy alone,as well as the patients' physical and mental state and treatment-related adverse reactions,were observed.Results The male to female ratio of enrolled patients was around 1︰1,and there was no statistically significant difference in general clinical information between the groups.The effective rate in the observation group was 54％,significantly higher than the 32％ in the control group ( P<0.05 ) .Regarding quality of life,the scores of the two groups of patients before treatment were similar,with no statistical significance ( P>0.05 ) .After treatment,the quality of life of both groups was significantly improved compared to before treatment ( P<0.05 ),and the quality of life in the observation group was significantly higher than in the control group,with statistical significance ( P<0.05 ) .The incidence of adverse reactions was similar between the two groups,with no significant difference ( P>0.05 ) .Conclusion Radiotherapy combined with FOLFOX4 chemotherapy for liver cancer complicated by portal vein thrombosis is effective,with minimal side effects,and improves the physical and mental state of patients.This approach is worth clinical consideration.
Hepatocellular carcinomaRadiation therapyPortal vein cancer thrombusQuality of lifeAdverse reactions
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维普
