Therapeutic Study of Scorpion Scald Oil on Deep Second-Degree Scald in Mice
Objective To explore the therapeutic effect of scorpion scald oil on deep second-degree scald in mice and its mechanism of promoting wound healing.Methods A total of 140 healthy SPF-grade Balb-c mice,aged 6-8 weeks,with a body weight of 18-23 g,were randomly divided into the scald model group,scorpion scald oil group,sulfadiazine silver group,and MEBO group,with 35 mice in each group.The model of deep second-degree scald in mice was established.After 2 hours of debridement,the scald model group was treated with 0.9％ saline,while the other drug intervention groups were treated with 0.5 g of the corresponding drug,evenly applied to the wound surface.Dressings were changed once in the morning and evening.The wound healing rate and wound healing time were measured.The microvessel density ( MVD ) of scalded wound tissue was measured by immunohistochemical method.Results On the 7th,14th,and 21st days after administration,the wound healing rate in the scorpion scald oil group was significantly higher than that in the scald model group at the same time points ( P<0.05 ) .The wound healing time in the scorpion scald oil group was significantly shorter than that in the scald model group ( P<0.05 ) .On the 7th,14th,and 21st days after administration,the MVD in the scorpion scald oil group was significantly higher than that in the scald model group ( P<0.05 ) .Conclusion Scorpion scald oil has a good protective effect on deep second-degree scald in mice,which may be related to its promotion of wound microangiogenesis,effectively accelerating wound healing and repair.
Scorpion scald oilDeep second-degree scaldWound healing rateWound healing timeMicrovessel density
万方数据
维普
