Comparison of Pemetrexed Disodium and Platinum in Non-Small Cell Lung Cancer Before and After Pharmaceutical Intervention in a Hospital
Objective To analyze the changes in rational drug use of pemetrexed disodium and platinum in non-small cell lung cancer ( NSCLC ) before and after pharmaceutical intervention and to guide rational clinical use.Methods A retrospective investigation was conducted with 50 cases in the pre-intervention group and 50 cases in the post-intervention group.Analysis and assessment were conducted across multiple aspects,including dosage and administration,indications for drug use,preparation,sequence of drug administration,pre-treatment procedures,selection of solvents,and drug interactions.Results After intervention,the rates of unreasonable drug combination use,pretreatment,and selection of antiemetic regimens were significantly reduced compared to before intervention ( P<0.05 ) .The occurrence of improper folic acid,vitamin B12,and dexamethasone monotherapy or improper combined therapy was also significantly lower after intervention ( P<0.05 ) .Conclusion Pharmaceutical interventions improve the rationality of pemetrexed disodium and platinum drug combination use and enhance patient compliance and drug safety.
Pharmaceutical interventionPemetrexed disodiumPlatinum compoundsNon-small cell lung cancerRational drug use
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