Application of Nasoexpiratory Nitric Oxide Detection in the Evaluation of Efficacy of Endoscopic Surgery in Patients with Rhinosinusitis and Nasal Polyps
Objective To evaluate the clinical efficacy of nasoexpiratory nitric oxide (nNO) in endoscopic surgery for patients with rhinosinusitis and nasal polyps. Methods Ninety-six patients with sinusitis and nasal polyps admit-ted to our hospital from September 2023 to February 2024 were selected,all of whom were treated with nasal endoscopic surgery. The efficacy of nasal endoscopic surgery was statistically analyzed for these patients,and they were divided into effective group (n=84) and ineffective group (n=12) according to the efficacy. The nNO values before and after treatment were compared between the effective group and the ineffective group,and the factors influencing the efficacy of nasal en-doscopic surgery in rhinosinusitis and nasal polyps were analyzed using binary Logistic regression. Receiver Operating Characteristic (ROC) curve analysis was conducted to evaluate the role of nNO in assessing the efficacy of endoscopic sinus surgery for patients with rhinosinusitis and nasal polyps. Results IAmong the 96 patients,endoscopic surgery resulted in significant improvement in 51 cases (53.12％),moderate improvement in 33 cases (34.38％),and no improve-ment in 12 cases (12.50％). The total efficiency of endoscopic surgery was 87.50％ (84/96). There was no significant dif-ference in nNO levels between the effective group and the ineffective group before treatment (P>0.05). After treatment,nNO levels increased significantly in both groups,with higher values in the effective group compared to the ineffective group (P<0.05). The Lund-Mackay scores and Visual Analogue Scale (VAS) scores were significantly lower in the effec-tive group than in the ineffective group (both P<0.05). Logistic regression analysis revealed that VAS score (OR=2.620,95％CI:1.516-4.526) and nNO (OR=2.821,95％CI:1.738-4.577) were significant factors influencing the efficacy of surgery (P<0.05). The AUC for nNO in assessing the efficacy of endoscopic sinus surgery was 0.891 (95％CI:0.841-0.936). Conclusion nNO levels increase after endoscopic surgery in patients with rhinosinusitis and nasal polyps,and nNO detection has significant value in evaluating the efficacy of the treatment.
Nasal and expiratory nitric oxideNasal endoscopic surgeryRhinosinusitis nasal polypCurative effectevaluate
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