Relationship Between Serum ox-LDL and LH/FSH Levels and Treatment Outcomes in Infertile Patients with Polycystic Ovarian Syndrome
Objective To investigate the relationship between serum oxidized low-density lipoprotein (ox-LDL),luteinizing hormone/follicle-stimulating hormone (LH/FSH) levels,and treatment outcomes in infertile patients with poly-cystic ovary syndrome (PCOS). Methods A total of 160 infertile patients with PCOS (PCOS infertility group) and 80 healthy women (control group) were selected. The PCOS infertility patients were further divided into a poor outcome group (99 patients) and a good outcome group (61 patients) based on their treatment outcomes. Enzyme-linked immunosorbent assay was used to measure ox-LDL levels and calculate LH/FSH ratios. Multifactorial unconditional logistic regression was employed to determine the influencing factors,using treatment outcomes of PCOS infertility patients as the dependent vari-able. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive efficiency of serum ox-LDL and LH/FSH levels. Results Serum ox-LDL and LH/FSH levels in the PCOS infertility group were significantly higher than those in the control group (all P<0.05). The poor treatment outcome rate was 61.88％ (99/160) among PCOS infertility pa-tients. Serum ox-LDL and LH/FSH levels in the poor outcome group were higher than those in the good outcome group (all P<0.05). Independent risk factors for poor treatment outcomes in PCOS infertility patients included homeostatic model as-sessment-insulin resistance,ox-LDL,and LH/FSH. The area under the ROC curve (AUC) for predicting poor treatment out-comes using combined serum ox-LDL and LH/FSH levels was greater than that for ox-LDL or LH/FSH alone (all P<0.05). Conclusion Elevated serum ox-LDL and LH/FSH levels are strongly associated with poor treatment outcomes in PCOS infertility patients,and their combination provides high predictive efficacy.
万方数据
维普
