Relationship Between Peripheral Blood Mpvlr in the Second Trimester of Pregnancy and Pregnancy Outcome in Patients with Hypothyroidism
Objective To explore the relationship between the mean platelet volume/lymphocyte ratio (MPVLR) of peripheral blood in the second trimester of pregnancy and the pregnancy outcome of hypothyroidism (hypothyroid-ism). Methods 136 pregnant women with hypothyroidism admitted to Aba Prefecture People's Hospital from March 2021 to August 2023 were selected as the research subjects. The predictive value of MPVLR on pregnancy outcomes in patients with hypothyroidism during pregnancy was evaluated by ROC,according to the MPVLR cutoff values,and divide them into a low MPVLR group (<4.89) of 87 cases and a high MPVLR group ( ≥ 4.89) of 49 cases;Follow up until the end of pregnancy,divided into a normal pregnancy outcome group of 109 cases and an adverse pregnancy outcome group of 27 cases based on pregnancy outcomes;The adverse pregnancy outcomes of patients with different MPVLR levels of pregnancy com-bind with hypothyroidism were compard;Using a multivariate logistic stepwise regression model to analyze and explore the influencing factors of pregnancy outcomes in patients with hypothyroidism during pregnancy. Results The area under the curve (AUC) (95％ CI) of MPVLR for predicting pregnancy outcomes in patients with hypothyroidism is 0.863 (0.811～0.915),with a cut-off value of 4.89,specificity of 0.662,and sensitivity of 0.921. According to the MPVLR cutoff value,the group was divided into a low MPVLR group (MPVLR<4.89,n=87) and a high MPVLR group (MPVLR ≥ 4.89,n=49). The in-cidence of adverse pregnancy outcomes in the high MPVLR group was higher compared with low MPVLR group(P<0.05). The proportion of women with adverse pregnancy outcomes over 30 years old,those with a history of miscarriage,TSH levels were higher than those in the normal pregnancy outcome group,while FT3 and FT4 levels were lower compared with nor-mal pregnancy outcome group(P<0.05). Multivariate regression analysis showed that age>30 years old (OR=2.487,95％ CI:1.645～3.761),elevated TSH levels (OR=2.323,95％ CI:1.558～3.465),and MPVLR ≥ 4.89 (OR=3.053,95％ CI:1.949～4.782) were independent risk factors for adverse pregnancy outcomes(P<0.05). Conclusion The elevated level of MPVLR in peripheral blood is related with adverse pregnancy outcomes in cases with hypothyroidism,and can be used as a biomarker to predict pregnancy out-comes in cases with hypothyroidism.
mean platelet volume/lymphocyte ratioSecond trimesterHypothyroidismPregnancy outcome
万方数据
维普
